DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zfh1 and zeb2a

DIOPT Version :9

Sequence 1:	NP_733401.3	Gene:	zfh1 / 43650	FlyBaseID:	FBgn0004606	Length:	1206	Species:	Drosophila melanogaster
Sequence 2:	NP_001108023.2	Gene:	zeb2a / 100003889	ZFINID:	ZDB-GENE-070912-553	Length:	1218	Species:	Danio rerio

Alignment Length:	1262	Identity:	327/1262 - (25%)
Similarity:	475/1262 - (37%)	Gaps:	414/1262 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 SLSEHIASEHPHDKL---------------NCGAAQPESDAEDEQSNMSG-----------SSRR 126
            |:.:.|.:|.|..|.               |...|...||.||......|           :|.|
Zfish    17 SMKQEIMAEGPRCKRRKQANPRRKNVLSYENVVDAGSGSDDEDRLLGSEGEGSPAGVPSLEASPR 81

  Fly   127 YAKSPLA---SNNNSSTANANNNSTSSQSMNNNSELAKNHNSANKMSPMCS-----PGSLTPGDL 183
            .|.:.|:   ...|.|...|..:......:|.:.|....:||   |||..|     .|::...|.
Zfish    82 VAHALLSCRGDEENESQDGAGAHVWRHGELNGSEERKAEYNS---MSPDISLHGIGNGTVKGIDA 143

  Fly   184 FAQLQHPPPQLPPHLHAQFMAAAASLAMQSARTASSPSQQQQQQLQQQQQLQQQQQHQMAMQQLL 248
            .::|:            .|.|                          :::|...:.|..::.:.|
Zfish   144 SSELE------------SFFA--------------------------KRKLDDGEGHAASIAEYL 170

  Fly   249 P------PQLPGSNSSVGSNSA-------YDLDLSAPRSTSSPGSTTGDLSGAYPCMQCTASFAS 300
            .      |:.|...:.:|:..|       .||.|..|.:          .:....|..|...:..
Zfish   171 QDTVIIYPEDPEEGTRLGTPEANGQDENENDLALRTPDA----------FAQLLTCPYCDRGYKR 225

  Fly   301 REQLEQH-EQLHSPCGPAAVSNVSQTCRICHKAFANVYRLQRHMISH----DESALL------RK 354
            ...|::| :..|..      ::.|..|.:|...||...:|:|||.:|    |:..||      ||
Zfish   226 LTSLKEHIKYRHEK------NDESFPCPLCSDTFAYRTQLERHMATHKPARDQPQLLNEGAGNRK 284

  Fly   355 FKCKECDKAFKFKHHLKEHVRIHSGEKPFGCDNCGKRFSHSGSFSSHMTSKKCISMGLKLN---- 415
            |||.||.||||:|||||||:||||||||:.|.||.||||||||:|||::|||||.: :.:|
Zfish   285 FKCTECGKAFKYKHHLKEHLRIHSGEKPYECSNCKKRFSHSGSYSSHISSKKCIGL-ISINGRVR 348

  Fly   416 ---NNR--ALLKRLEKSPGSASSASRRSPSDHGKGKLPEQPSLPGLPH------PM--------- 460
               ||:  :.......||||.:.|..|...::|:....:.||    .|      ||
Zfish   349 HGVNNKPGSSPNSAASSPGSPALAQLRHKLENGRSMSLQDPS----AHTDIKSEPMDFNEYRLMI 409

  Fly   461 ----SYFASDAQVQGGSAAPAPFPPFHPNYMNAALLAFPHNFMAAAAGLDPRVHPY--------- 512
                .|.||.|.:.||....:| |..|.:..|    ...|      .|:....||.
Zfish   410 ASQQEYGASGAFLNGGGRGGSP-PGMHSSSQN----PLQH------LGIGSDSHPLGYTGFINNM 463

  Fly   513 -SIQRLLQL--SAAGQQQREEEREEQQKQQQHDEEETPDEPKLVMDIEEPETKEMAPTP------ 568
             .:|::||:  :...:|:.:...||..|.:.:.:|       |...:|| :.:.:|...
Zfish   464 SEVQKVLQIVDNTVCRQKMDGNPEEISKLRAYMKE-------LGSQMEE-QNRVLASQQSFLGVG 520

  Fly   569 --EATEAATPIKREESREASPDPESYRSSSQAIKQEQEPLNVAEERQTPVEEHAPVEHAADL--- 628
              ..|:.......|:..||....:|....|     ::..:::.:||.:         ||.||
Zfish   521 HNSPTKTIIDYTLEKVNEAKACLQSLTEDS-----KRRLMDIKKERPS---------HAMDLLSE 571

  Fly   629 -------------RCSRCSKQFNHPTELVQHEKVLCGLIKEELEQHFQ---------------QQ 665
                         .|..|.:.|:.|..|.|||:.||.: .||::...:               :|
Zfish   572 DKALERDAQYAPFSCQYCKETFSGPIPLHQHERYLCKM-NEEIKAVLKPNDTVPTGRRGLFGSEQ 635

  Fly   666 QATSFALASASEEDEEDEEMDVEEEPRQESGERKVRVRTAIN--EEQQQQLKQHYSLNARPSRDE 728
            ||.  .::|:.|.:                      ..:.:|  ::....|..::|:|..|:.:|
Zfish   636 QAG--VISSSLERN----------------------ATSPVNPYKDHMSLLNVYFSMNTEPNSEE 676

  Fly   729 FRMIAARLQLDPRVVQVWF-----QNNRSRERK-------------------------------- 756
            .|.|:..:.|....|:..|     |::.|..||
Zfish   677 LRKISMAVGLPQEFVKDAFVQWKAQSHHSFSRKRSPPPERSGETNHVRDSAFARSPVSLGQYGDS 741

  Fly   757 ---MQSFQNNQAA---------------------------GAAP-PMPIDSQA------------ 778
               :|:..|..:.                           |..| |:.:.|.:
Zfish   742 TAEIQAITNGDSGHKLSRTHQITGTRQTNEKPLDSVDHLRGETPSPLNLSSSSSKHSHSSSYTPN 806

  Fly   779 SLTRED---QPLDLSVKRDPLTPKSESSPPYIAPPSGEAL-----------NPEAINLS---RKF 826
            |||.||   :|||||:      ||..|.....|.|:|.::           ..|.:||:   ::|
Zfish   807 SLTSEDAHGEPLDLSL------PKQVSKAERRAKPNGFSIEHTSNSTAREPGTEPLNLAHIKKEF 865

  Fly   827 S----------TSASMSPA-SISPSSAAALY-----FGAAPPPSPPNSQLDSTPRSGQAFPGLPP 875
            :          ...|.||. ||:|.....:|     .||.|||:     ..||.::  :.|||.|
Zfish   866 NGPNSLGNENQMDKSSSPIFSINPFGGGHMYTSLPPHGAFPPPT-----FMSTTQA--SIPGLRP 923

  Fly   876 Y--MLPMS-LPMEALFKMRPGGDFASNHALMNSIKLPDYRGTSLSPGG---SEKRSWRDDDSRIS 934
            |  :.||| ||..|.........||.........:...::|..|...|   |......|.:|.::
Zfish   924 YPGLDPMSFLPPMAYTYAAGAATFAEMQQRRKYQRKQGFQGDLLDSAGDYLSGLEDLTDSESLLA 988

  Fly   935 HEDEFGAGVLMPPKPRRGKAETHGHAGDPDLPYVCDQCDKAFAKQSSLARHKYEHSGQRPYQCIE 999
            .              ::.|....|       .|.||.|||.|.|.|||.||||||:|:||:||..
Zfish   989 R--------------KKIKKTESG-------MYACDLCDKTFQKTSSLLRHKYEHTGKRPHQCQI 1032

  Fly  1000 CPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYREXVSDTSVPPT 1064
            |.|||||||||.||.||||||||:||.||.|||||||||||||||||||||  ||.....:....
Zfish  1033 CKKAFKHKHHLIEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCK--REAEEREAAKQE 1095

  Fly  1065 CQPGANPLAPPAMASNRGRRRVQVPAG 1091
            ......||.|..:...|...:...|.|
Zfish  1096 NHNNGGPLEPTELLMRRAYLQGLGPLG 1122

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zfh1	NP_733401.3	C2H2 Zn finger	291..311	CDD:275368	4/20 (20%)
		C2H2 Zn finger	326..346	CDD:275368	8/19 (42%)
		zf-C2H2	355..377	CDD:278523	17/21 (81%)
		C2H2 Zn finger	357..377	CDD:275368	15/19 (79%)
		zf-H2C2_2	369..391	CDD:290200	16/21 (76%)
		Homeobox	703..755	CDD:278475	13/58 (22%)
		C2H2 Zn finger	969..989	CDD:275368	14/19 (74%)
		zf-H2C2_2	981..1006	CDD:290200	17/24 (71%)
		COG5048	992..>1045	CDD:227381	42/52 (81%)
		C2H2 Zn finger	997..1017	CDD:275368	14/19 (74%)
		zf-H2C2_2	1009..1034	CDD:290200	19/24 (79%)
		C2H2 Zn finger	1025..1042	CDD:275368	14/16 (88%)
zeb2a	NP_001108023.2	C2H2 Zn finger	216..237	CDD:275368	4/20 (20%)
		C2H2 Zn finger	246..266	CDD:275368	8/19 (42%)
		zf-C2H2	285..307	CDD:306579	17/21 (81%)
		C2H2 Zn finger	287..307	CDD:275368	15/19 (79%)
		zf-H2C2_2	299..322	CDD:316026	17/22 (77%)
		C2H2 Zn finger	1002..1022	CDD:275368	14/19 (74%)
		zf-H2C2_2	1014..1039	CDD:316026	17/24 (71%)
		C2H2 Zn finger	1030..1050	CDD:275368	14/19 (74%)
		zf-H2C2_2	1042..1067	CDD:316026	19/24 (79%)
		C2H2 Zn finger	1058..1075	CDD:275368	14/16 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11653
eggNOG	1	0.900	-	-		E1_KOG3623
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	294	1.000	Inparanoid score	I2747
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380919at33208
OrthoFinder	1	1.000	-	-		FOG0002059
OrthoInspector	1	1.000	-	-		otm24430
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24391
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1522
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	10.020