DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Npc2h and NPC2

DIOPT Version :9

Sequence 1:	NP_001247376.1	Gene:	Npc2h / 43649	FlyBaseID:	FBgn0039801	Length:	157	Species:	Drosophila melanogaster
Sequence 2:	NP_001350617.1	Gene:	NPC2 / 10577	HGNCID:	14537	Length:	174	Species:	Homo sapiens

Alignment Length:	157	Identity:	41/157 - (26%)
Similarity:	72/157 - (45%)	Gaps:	20/157 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LPVAFALVLSSVS--AEIVNFQTCEDSVDSCSISQVRVTPCPEANANAACHIRRRHRFTMSFDFT 70
            |...|.|:..|.:  ||.|.|:.| .|||.. |.:|.|:|||    ...|.:.:...::::..||
Human     4 LAATFLLLALSTAAQAEPVQFKDC-GSVDGV-IKEVNVSPCP----TQPCQLSKGQSYSVNVTFT 62

  Fly    71 PHFDADTLVA-----SLGWAKSENVELPLLTMDQEACKY-TTCPVRSGVTQTYTNNMPADARFPL 129
            .:..:.:..|     .:|      |.:|....:.:.||. ..||::...|.:|.|.:|..:.:|.
Human    63 SNIQSKSSKAVVHGILMG------VPVPFPIPEPDGCKSGINCPIQKDKTYSYLNKLPVKSEYPS 121

  Fly   130 SPYTIRWALKDPVSQKRCCFTIDIKVV 156
            ....:.|.|:|..:|...|:.|.:::|
Human   122 IKLVVEWQLQDDKNQSLFCWEIPVQIV 148

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Npc2h	NP_001247376.1	Npc2_like	26..153	CDD:238458	33/132 (25%)
NPC2	NP_001350617.1	Npc2_like	24..145	CDD:238458	33/132 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11306
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.970