DRSC/TRiP Functional Genomics Resources

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Protein Alignment eIF4H2 and EIF4B

DIOPT Version :10

Sequence 1:NP_651820.1 Gene:eIF4H2 / 43645 FlyBaseID:FBgn0039797 Length:459 Species:Drosophila melanogaster
Sequence 2:NP_001287750.1 Gene:EIF4B / 1975 HGNCID:3285 Length:616 Species:Homo sapiens


Alignment Length:400 Identity:92/400 - (23%)
Similarity:145/400 - (36%) Gaps:126/400 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 RDRDRDRQRQVPTEPPFIAYVGNLPKGLVQGDVMKIFSDFEVKNVRLIKDRETDE-FKGYGYVEF 110
            |:.:.||.| :|..||:.|::||||..:.:..:.:.|....:..|||.::....| .||:||.||
Human    81 REPNIDRSR-LPKSPPYTAFLGNLPYDVTEESIKEFFRGLNISAVRLPREPSNPERLKGFGYAEF 144

  Fly   111 ETLAQLKSALNCNGRIKLDNFSAPLRIDIADHRRQNPGAPSGVGGAPPAGVGHERGGGVGRGGST 175
            |.|..|.|||:.|.. .|.|  ..:|:|:||                                  
Human   145 EDLDSLLSALSLNEE-SLGN--RRIRVDVAD---------------------------------- 172

  Fly   176 GAANGNNPYYQRRNYRRDDSVGSHQFRRREPRSNSSNHQMSNSSPTQSTTSINYNRTTRG--GFN 238
                      |.::..|||    ..|.|...|.:........:.|  :|.|.:.....||  .|.
Human   173 ----------QAQDKDRDD----RSFGRDRNRDSDKTDTDWRARP--ATDSFDDYPPRRGDDSFG 221

  Fly   239 SRVAVGGNGNRYQGGAPRNFND---REDQQSTGSGGFQRNRTYNFNRSMNNSVGGGGAGVGRGGH 300
            .:.....:.:||:.|....:.|   |:..:..|...:....:.:::|..::.:|.|....|.|..
Human   222 DKYRDRYDSDRYRDGYRDGYRDGPRRDMDRYGGRDRYDDRGSRDYDRGYDSRIGSGRRAFGSGYR 286

  Fly   301 PQRNFNGNGGGGGFGVVNGGGNYTNFVQNRNRDRRGHYNPNHSGSSGGYNNNGNNTFGGENNHPV 365
            ...::.|.|                   :|..||              |:...:.::...:::. 
Human   287 RDDDYRGGG-------------------DRYEDR--------------YDRRDDRSWSSRDDYS- 317

  Fly   366 HGASESASSGTGPSSSNQFAVRDD---DD-----RPKLVLKPRTVTAPINSLAETKQ---AALIF 419
                                 |||   ||     ||||.||||:.....:|.|.|.|   ||.||
Human   318 ---------------------RDDYRRDDRGPPQRPKLNLKPRSTPKEDDSSASTSQSTRAASIF 361

  Fly   420 GKAKPRDDSS 429
            |.|||.|.::
Human   362 GGAKPVDTAA 371

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eIF4H2NP_651820.1 RRM_SF 58..144 CDD:473069 32/86 (37%)
EIF4BNP_001287750.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..37
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 66..93 5/12 (42%)
RRM_eIF4B 94..175 CDD:409836 32/127 (25%)
PRK12678 <158..>273 CDD:237171 26/167 (16%)
PTZ00108 <372..613 CDD:240271 92/399 (23%)
Blue background indicates that the domain is not in the aligned region.

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