Protein Alignment eIF4H2 and Rbm39

DIOPT Version :10

• Sequence 1: NP_651820.1
• Gene: eIF4H2 / 43645
• FlyBaseID: FBgn0039797
• Length: 459
• Species: Drosophila melanogaster
• Sequence 2: NP_573505.2
• Gene: Rbm39 / 170791
• MGIID: 2157953
• Length: 530
• Species: Mus musculus
• Alignment Length: 214
• Identity: 41/214 - (19%)
• Similarity: 76/214 - (35%)
• Gaps: 62/214 - (28%)

  Fly     3 NRSSQRDREFNRDNTYNNNRDNRDHNRDNRDNRENRSNFQNYRNRDRDRDR-------------- 53
            :||...:|:.::......:||.......:|:.:.:||. :..|:|.|.|||
Mouse    40 SRSRSHERKRSKSKERKRSRDRERKKSKSRERKRSRSK-ERRRSRSRSRDRRFRGRYRSPYSGPK 103

  Fly    54 ------------------QRQVPTEPPF----------------------IAYVGNLPKGLVQGD 78
                              :|:..::.||                      ..:...|...:...|
Mouse   104 FNSAIRGKIGLPHSIKLSRRRSRSKSPFRKDKSPVREPIDNLTPEERDARTVFCMQLAARIRPRD 168

  Fly    79 VMKIFSDF-EVKNVRLIKDRETDEFKGYGYVEFETLAQLKSALNCNGRIKLDNFSAPLRIDIADH 142
            :.:.||.. :|::||:|.||.:...||..||||..::.:..|:...|:..|   ..|:.:..:..
Mouse   169 LEEFFSTVGKVRDVRMISDRNSRRSKGIAYVEFVDVSSVPLAIGLTGQRVL---GVPIIVQASQA 230

  Fly   143 RRQNPGAPSG---VGGAPP 158
            .:....|.:.   .|.|.|
Mouse   231 EKNRAAAMANNLQKGSAGP 249

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF4H2	NP_651820.1	RRM_SF	58..144	CDD:473069	22/108 (20%)
Rbm39	NP_573505.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..146		17/106 (16%)
		SF-CC1	46..518	CDD:273721	39/208 (19%)
		Interaction with JUN. /evidence=ECO:0000269|PubMed:11704680	291..406
		Activating domain	291..355
		Interaction with ESR1 and ESR2. /evidence=ECO:0000269|PubMed:11704680	355..406
		Interaction with NCOA6. /evidence=ECO:0000269|PubMed:11704680	406..530