Protein Alignment eIF4H2 and CIRBP

DIOPT Version :10

• Sequence 1: NP_651820.1
• Gene: eIF4H2 / 43645
• FlyBaseID: FBgn0039797
• Length: 459
• Species: Drosophila melanogaster
• Sequence 2: NP_001287758.1
• Gene: CIRBP / 1153
• HGNCID: 1982
• Length: 297
• Species: Homo sapiens
• Alignment Length: 198
• Identity: 54/198 - (27%)
• Similarity: 81/198 - (40%)
• Gaps: 44/198 - (22%)

  Fly    66 YVGNLPKGLVQGDVMKIFSDF-EVKNVRLIKDRETDEFKGYGYVEFETLAQLKSALNC-NGRIKL 128
            :||.|.....:..:.::||.: ::..|.::|||||...:|:|:|.||.:...|.|:.. ||: .:
Human     9 FVGGLSFDTNEQSLEQVFSKYGQISEVVVVKDRETQRSRGFGFVTFENIDDAKDAMMAMNGK-SV 72

  Fly   129 DNFSAPLRIDIADHRRQNPGAPSGVGGAPPAGVGHERGG-GVGRGGSTGAANGNNPYYQRRNYRR 192
            |  ...:|:|.|.....|  ...|..|....|.|..||| |.|||.|.|..:        |.|
Human    73 D--GRQIRVDQAGKSSDN--RSRGYRGGSAGGRGFFRGGRGRGRGFSRGGGD--------RGY-- 123

  Fly   193 DDSVGSHQFRRREPRSNSSNHQMSNSSPTQSTTSINYNRTTRGGFNSRVAVGGNGNRYQGGAPRN 257
                |.::|..|......|                      |..::||...||..:|..||:.|:
Human   124 ----GGNRFESRSGGYGGS----------------------RDYYSSRSQSGGYSDRSSGGSYRD 162

  Fly   258 FND 260
            ..|
Human   163 SYD 165

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF4H2	NP_651820.1	RRM_SF	58..144	CDD:473069	24/79 (30%)
CIRBP	NP_001287758.1	RRM_CIRBP_RBM3	6..85	CDD:409883	24/78 (31%)