Protein Alignment Pka-C2 and RPS6KA5

DIOPT Version :10

• Sequence 1: NP_733397.2
• Gene: Pka-C2 / 43644
• FlyBaseID: FBgn0000274
• Length: 354
• Species: Drosophila melanogaster
• Sequence 2: NP_004746.2
• Gene: RPS6KA5 / 9252
• HGNCID: 10434
• Length: 802
• Species: Homo sapiens
• Alignment Length: 311
• Identity: 112/311 - (36%)
• Similarity: 178/311 - (57%)
• Gaps: 14/311 - (4%)

  Fly    42 LENYITRAVLGNGSFGTVMLVREKSGKN---YYAAKMMSKEDLV-RLKQVAHVHNEKHVLNAAR- 101
            :||:....|||.|::|.|.|||:.||.:   .||.|::.|..:| :.|...|...|:.||...|
Human    46 IENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQ 110

  Fly   102 FPFLIYLVDSTKCFDYLYLILPLVNGGELFSYHRRVRKFNEKHARFYAAQVALALEYMHKMHLMY 166
            .|||:.|..:.:....|:|||..:||||||::..:..:|.|...:.|..::.||||::||:.::|
Human   111 SPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIY 175

  Fly   167 RDLKPENILLDQRGYIKITDFGFTKRV----DGRTSTLCGTPEYLAPEIVQ--LRPYNKSVDWWA 225
            ||:|.||||||..|::.:||||.:|..    ..|..:.|||.||:||:||:  ...::|:||||:
Human   176 RDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWS 240

  Fly   226 FGILVYEFVAGRSPFAI--HNRDVILMYSKICICDYKMPSYFTSQLRSLVESLMQVDTSKRLGNS 288
            .|:|:||.:.|.|||.:  .......:..:|...:...|...::..:.|::.|:..|..||||..
Human   241 LGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCG 305

  Fly   289 NDGSSDVKSHPWFQGVDWFGILNQEVTAPYQPTISGAEDLSNF-ENFEFKD 338
            ...:.::|.|.:||.::|..:..::|.||::|.|....|:||| |.|...|
Human   306 PRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMD 356

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C2	NP_733397.2	Protein Kinases, catalytic domain	43..334	CDD:473864	110/304 (36%)
RPS6KA5	NP_004746.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		STKc_MSK1_N	48..337	CDD:270764	102/288 (35%)
		S_TK_X	320..379	CDD:214529	13/37 (35%)
		STKc_MSK1_C	418..727	CDD:271081
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	741..802