Protein Alignment Pka-C2 and TPK1

DIOPT Version :10

• Sequence 1: NP_733397.2
• Gene: Pka-C2 / 43644
• FlyBaseID: FBgn0000274
• Length: 354
• Species: Drosophila melanogaster
• Sequence 2: NP_012371.2
• Gene: TPK1 / 853275
• SGDID: S000003700
• Length: 397
• Species: Saccharomyces cerevisiae
• Alignment Length: 366
• Identity: 149/366 - (40%)
• Similarity: 218/366 - (59%)
• Gaps: 40/366 - (10%)

  Fly    22 NMSREFEERWNHQTQSP------YTNLENY---ITRA----------------VLGNGSFGTVML 61
            |.|:..|:......:.|      |.|.|.|   |.:|                .||.||||.|.|
Yeast    39 NESKSVEKEGGETQEKPKQPHVTYYNEEQYKQFIAQARVTSGKYSLQDFQILRTLGTGSFGRVHL 103

  Fly    62 VREKSGKNYYAAKMMSKEDLVRLKQVAHVHNEKHVLNAARFPFLIYLVDSTKCFDYLYLILPLVN 126
            :|.:....|||.|::.||.:||||||.|.::|:.:|:....||:|.:..:.:....:::|:..:.
Yeast   104 IRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRMWGTFQDAQQIFMIMDYIE 168

  Fly   127 GGELFSYHRRVRKFNEKHARFYAAQVALALEYMHKMHLMYRDLKPENILLDQRGYIKITDFGFTK 191
            ||||||..|:.::|....|:||||:|.|||||:|...::||||||||||||:.|:||||||||.|
Yeast   169 GGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAK 233

  Fly   192 RVDGRTSTLCGTPEYLAPEIVQLRPYNKSVDWWAFGILVYEFVAGRSPFAIHNRDVILMYSKICI 256
            .|...|.||||||:|:|||:|..:|||||:|||:||||:||.:||.:||  ::.:.:..|.||..
Yeast   234 YVPDVTYTLCGTPDYIAPEVVSTKPYNKSIDWWSFGILIYEMLAGYTPF--YDSNTMKTYEKILN 296

  Fly   257 CDYKMPSYFTSQLRSLVESLMQVDTSKRLGNSNDGSSDVKSHPWFQGVDWFGILNQEVTAPYQPT 321
            .:.:.|.:|...::.|:..|:..|.|:||||..:|:.|||:||||:.|.|..:|::.:..||:|.
Yeast   297 AELRFPPFFNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFKEVVWEKLLSRNIETPYEPP 361

  Fly   322 I-SGAEDLSNFENFEFKDRYKSRIN-------RHPELFANF 354
            | .|..|.|.|:.:..:|     ||       .:.:||.:|
Yeast   362 IQQGQGDTSQFDKYPEED-----INYGVQGEDPYADLFRDF 397

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C2	NP_733397.2	Protein Kinases, catalytic domain	43..334	CDD:473864	137/310 (44%)
TPK1	NP_012371.2	STKc_PKA_like	85..375	CDD:270732	133/291 (46%)