Protein Alignment Pka-C2 and RPS6KA1

DIOPT Version :10

• Sequence 1: NP_733397.2
• Gene: Pka-C2 / 43644
• FlyBaseID: FBgn0000274
• Length: 354
• Species: Drosophila melanogaster
• Sequence 2: NP_001006666.1
• Gene: RPS6KA1 / 6195
• HGNCID: 10430
• Length: 744
• Species: Homo sapiens
• Alignment Length: 305
• Identity: 107/305 - (35%)
• Similarity: 181/305 - (59%)
• Gaps: 28/305 - (9%)

  Fly    50 VLGNGSFGTVMLVRE----KSGKNYYAAKMMSK-----EDLVRLKQVAHVHNEKHVLNAARFPFL 105
            |||.||||.|.|||:    .|| :.||.|::.|     .|.||.|.      |:.:|.....||:
Human    76 VLGQGSFGKVFLVRKVTRPDSG-HLYAMKVLKKATLKVRDRVRTKM------ERDILADVNHPFV 133

  Fly   106 IYLVDSTKCFDYLYLILPLVNGGELFSYHRRVRKFNEKHARFYAAQVALALEYMHKMHLMYRDLK 170
            :.|..:.:....|||||..:.||:||:...:...|.|:..:||.|::||.|:::|.:.::|||||
Human   134 VKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLK 198

  Fly   171 PENILLDQRGYIKITDFGFTKRV---DGRTSTLCGTPEYLAPEIVQLRPYNKSVDWWAFGILVYE 232
            |||||||:.|:||:||||.:|..   :.:..:.|||.||:|||:|..:.::.|.|||::|:|::|
Human   199 PENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFE 263

  Fly   233 FVAGRSPFAIHNRD---VILMYSKICICDYKMPSYFTSQLRSLVESLMQVDTSKRLGNSNDGSSD 294
            .:.|..||...:|.   .:::.:|:     .||.:.:::.:||:.:|.:.:.:.|||:..||:.:
Human   264 MLTGSLPFQGKDRKETMTLILKAKL-----GMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEE 323

  Fly   295 VKSHPWFQGVDWFGILNQEVTAPYQPTISGAEDLSNFENFEFKDR 339
            :|.|.::..:||..:..:|:..|::|.::..:|...|:. ||..|
Human   324 IKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDT-EFTSR 367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C2	NP_733397.2	Protein Kinases, catalytic domain	43..334	CDD:473864	104/298 (35%)
RPS6KA1	NP_001006666.1	STKc_RSK_N	75..391	CDD:270734	107/305 (35%)
		STKc_RSK1_C	425..715	CDD:271077