DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pka-C2 and PRKX

DIOPT Version :9

Sequence 1:	NP_733397.2	Gene:	Pka-C2 / 43644	FlyBaseID:	FBgn0000274	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_005035.1	Gene:	PRKX / 5613	HGNCID:	9441	Length:	358	Species:	Homo sapiens

Alignment Length:	321	Identity:	141/321 - (43%)
Similarity:	206/321 - (64%)	Gaps:	4/321 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 QSPYTNLENYITRAVLGNGSFGTVMLVREKSGKNYYAAKMMSKEDLVRLKQVAHVHNEKHVLNAA 100
            :.|..:|:::.|.|.:|.|:||.|.||:||:.|:::|.|:||..|::||||..||||||.||...
Human    40 EPPVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEV 104

  Fly   101 RFPFLIYLVDSTKCFDYLYLILPLVNGGELFSYHRRVRKFNEKHARFYAAQVALALEYMHKMHLM 165
            ..||||.|..:.....:||:::..|.|||||||.|...:|:.....||:|::..|:||:|...::
Human   105 SHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIV 169

  Fly   166 YRDLKPENILLDQRGYIKITDFGFTKRVDGRTSTLCGTPEYLAPEIVQLRPYNKSVDWWAFGILV 230
            ||||||||||||:.|:||:|||||.|::..||.||||||||||||::|.:.:.::|||||.|||:
Human   170 YRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILI 234

  Fly   231 YEFVAGRSPFAIHNRDVILMYSKICICDYKMPSYFTSQLRSLVESLMQVDTSKRLGNSNDGSSDV 295
            :|.::|..||...|...|  |.||.......|.:....::.|::.|:.||.::||||..:|::||
Human   235 FEMLSGFPPFFDDNPFGI--YQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDV 297

  Fly   296 KSHPWFQGVDWFGILNQEVTAPYQPTISGAEDLSNFENFEFKDRYKSR--INRHPELFANF 354
            |.|.||:.|||..:..:::..|..|.|:|..|.||||.:...|...:.  ..:..|:|.||
Human   298 KHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVPQKDLEIFKNF 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C2	NP_733397.2	PKc_like	43..334	CDD:328722	134/290 (46%)
PRKX	NP_005035.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		PTZ00263	39..358	CDD:140289	139/319 (44%)
		STKc_PRKX_like	47..338	CDD:270763	134/292 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0616
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D277423at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820