DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pka-C2 and PRKG1

DIOPT Version :9

Sequence 1:	NP_733397.2	Gene:	Pka-C2 / 43644	FlyBaseID:	FBgn0000274	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_006249.1	Gene:	PRKG1 / 5592	HGNCID:	9414	Length:	686	Species:	Homo sapiens

Alignment Length:	327	Identity:	114/327 - (34%)
Similarity:	186/327 - (56%)	Gaps:	14/327 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LDNMS----REFEERWNHQTQSPY---TNLENYITRAVLGNGSFGTVMLVREKSGKN-YYAAKMM 76
            ||::|    .:.|.:..::.::.:   ..|.::.....||.|.||.|.||:.||.:: .:|.|::
Human   343 LDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKIL 407

  Fly    77 SKEDLVRLKQVAHVHNEKHVLNAARFPFLIYLVDSTKCFDYLYLILPLVNGGELFSYHRRVRKFN 141
            .|..:|..:|..|:.:||.::..|...|::.|..:.|...|||:::....||||::..|....|.
Human   408 KKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFE 472

  Fly   142 EKHARFYAAQVALALEYMHKMHLMYRDLKPENILLDQRGYIKITDFGFTKRV--DGRTSTLCGTP 204
            :...|||.|.|..|..|:|...::||||||||::||.|||.|:.||||.|::  ..:|.|.||||
Human   473 DSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTP 537

  Fly   205 EYLAPEIVQLRPYNKSVDWWAFGILVYEFVAGRSPFAIHNRDVILMYSKIC--ICDYKMPSYFTS 267
            ||:||||:..:.::.|.|:|:.|||:||.:.|..||:  ..|.:..|:.|.  |...:.|.....
Human   538 EYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFS--GPDPMKTYNIILRGIDMIEFPKKIAK 600

  Fly   268 QLRSLVESLMQVDTSKRLGNSNDGSSDVKSHPWFQGVDWFGILNQEVTAPYQPTISGAEDLSNFE 332
            ...:|::.|.:.:.|:||||..:|..|::.|.||:|.:|.|:....:|.|..|:::...|.|||:
Human   601 NAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFD 665

  Fly   333 NF 334
            :|
Human   666 SF 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C2	NP_733397.2	PKc_like	43..334	CDD:328722	108/295 (37%)
PRKG1	NP_006249.1	DD_cGKI-beta	4..55	CDD:213375
		CAP_ED	118..227	CDD:237999
		CAP_ED	237..341	CDD:237999
		STKc_cGK	381..641	CDD:270724	100/261 (38%)
		S_TK_X	636..>679	CDD:214529	11/32 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142895
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840