Protein Alignment Pka-C2 and PRKCH

DIOPT Version :10

• Sequence 1: NP_733397.2
• Gene: Pka-C2 / 43644
• FlyBaseID: FBgn0000274
• Length: 354
• Species: Drosophila melanogaster
• Sequence 2: XP_047287541.1
• Gene: PRKCH / 5583
• HGNCID: 9403
• Length: 782
• Species: Homo sapiens
• Alignment Length: 327
• Identity: 114/327 - (34%)
• Similarity: 187/327 - (57%)
• Gaps: 21/327 - (6%)

  Fly    11 NSKEDYNVILDNMSREFEERWNHQTQSPYTNLENYITRAVLGNGSFGTVMLVREKSGKNYYAAKM 75
            :|||...:.:::.:|              ..::|:....|||.||||.|||.|.|...:.||.|:
Human   434 SSKEGNGIGVNSSNR--------------LGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKV 484

  Fly    76 MSKEDLVRLKQVAHVHNEKHVLNAAR-FPFLIYLVDSTKCFDYLYLILPLVNGGELFSYHRRVRK 139
            :.|:.:::...|.....||.:|:.|| .|||..|....:..|.|:.::..||||:|..:.::.|:
Human   485 LKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRR 549

  Fly   140 FNEKHARFYAAQVALALEYMHKMHLMYRDLKPENILLDQRGYIKITDFGFTKR--VDG-RTSTLC 201
            |:|..||||||::..||.::|...::|||||.:|:|||..|:.|:.|||..|.  .:| .|:|.|
Human   550 FDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFC 614

  Fly   202 GTPEYLAPEIVQLRPYNKSVDWWAFGILVYEFVAGRSPFAIHNRDVILMYSKICICDYKMPSYFT 266
            |||:|:||||:|...|..:|||||.|:|:||.:.|.:||...|.|.  ::..|...:...|::..
Human   615 GTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDD--LFEAILNDEVVYPTWLH 677

  Fly   267 SQLRSLVESLMQVDTSKRLGN-SNDGSSDVKSHPWFQGVDWFGILNQEVTAPYQPTISGAEDLSN 330
            .....:::|.|..:.:.|||: :..|...:..||:|:.:||..:.::::..|::|.|...||:||
Human   678 EDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSN 742

  Fly   331 FE 332
            |:
Human   743 FD 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C2	NP_733397.2	Protein Kinases, catalytic domain	43..334	CDD:473864	110/295 (37%)
PRKCH	XP_047287541.1	C2_PKC_epsilon	8..122	CDD:175981
		C1_nPKC_epsilon-like_rpt1	265..325	CDD:410385
		C1_nPKC_epsilon-like_rpt2	343..397	CDD:410388
		STKc_nPKC_eta	458..780	CDD:270742	109/289 (38%)