Protein Alignment Pka-C2 and PRKCD

DIOPT Version :10

• Sequence 1: NP_733397.2
• Gene: Pka-C2 / 43644
• FlyBaseID: FBgn0000274
• Length: 354
• Species: Drosophila melanogaster
• Sequence 2: NP_001341605.1
• Gene: PRKCD / 5580
• HGNCID: 9399
• Length: 695
• Species: Homo sapiens
• Alignment Length: 329
• Identity: 117/329 - (35%)
• Similarity: 191/329 - (58%)
• Gaps: 16/329 - (4%)

  Fly    21 DNMSREFEERWNHQTQSPYTNLENYITRAVLGNGSFGTVMLVREKSGKNYYAAKMMSKEDLVRLK 85
            || |..:.:.|...::   .|:.|:|...|||.||||.|:|...|....|:|.|.:.|:.::...
Human   348 DN-SGTYGKIWEGSSK---CNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDD 408

  Fly    86 QVAHVHNEKHVLN-AARFPFLIYLVDSTKCFDYLYLILPLVNGGELFSYHRRVRKFNEKHARFYA 149
            .|.....||.||. ||..|||.:|:.:.:..|:|:.::..:|||:|..:.:...:|....|.|||
Human   409 DVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYA 473

  Fly   150 AQVALALEYMHKMHLMYRDLKPENILLDQRGYIKITDFGFTKR---VDGRTSTLCGTPEYLAPEI 211
            |::...|:::|...::|||||.:|:|||:.|:|||.|||..|.   .:.|.||.||||:|:||||
Human   474 AEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEI 538

  Fly   212 VQLRPYNKSVDWWAFGILVYEFVAGRSPFAIHNRDVILMYSKICICDYKMPSYFTSQLRSLVESL 276
            :|...|..|||||:||:|:||.:.|:|||  |..|...::..|.:.....|.:.|.:.:.::|.|
Human   539 LQGLKYTFSVDWWSFGVLLYEMLIGQSPF--HGDDEDELFESIRVDTPHYPRWITKESKDILEKL 601

  Fly   277 MQVDTSKRLGNSNDGSSDVKSHPWFQGVDWFGILNQEVTAPYQPTISGAEDLSNFENFEFKDRYK 341
            .:.:.:||||    .:.::|.||:|:.::|..:..:.:..|::|.:....|.|||:. ||.:. |
Human   602 FEREPTKRLG----VTGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQ-EFLNE-K 660

  Fly   342 SRIN 345
            :|::
Human   661 ARLS 664

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C2	NP_733397.2	Protein Kinases, catalytic domain	43..334	CDD:473864	108/294 (37%)
PRKCD	NP_001341605.1	C1_nPKC_theta-like_rpt1	171..231	CDD:410384
		C1_nPKC_theta-like_rpt2	250..299	CDD:410387
		STKc_nPKC_delta	372..687	CDD:173710	110/301 (37%)