Protein Alignment Pka-C2 and PRKACG

DIOPT Version :10

• Sequence 1: NP_733397.2
• Gene: Pka-C2 / 43644
• FlyBaseID: FBgn0000274
• Length: 354
• Species: Drosophila melanogaster
• Sequence 2: NP_002723.2
• Gene: PRKACG / 5568
• HGNCID: 9382
• Length: 351
• Species: Homo sapiens
• Alignment Length: 333
• Identity: 155/333 - (46%)
• Similarity: 219/333 - (65%)
• Gaps: 4/333 - (1%)

  Fly    13 KEDYNVILDNMSREFEERWNHQTQSPYTNLENYITRAVLGNGSFGTVMLVREKSGKNYYAAKMMS 77
            :|..|..|.....:|..||.:..|:..:: :.:.....||.||||.|||||.:....:||.|:::
Human    13 EESVNEFLAKARGDFLYRWGNPAQNTASS-DQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILN 76

  Fly    78 KEDLVRLKQVAHVHNEKHVLNAARFPFLIYLVDSTKCFDYLYLILPLVNGGELFSYHRRVRKFNE 142
            |:.:|::|||.|:.|||.:|.|..||||:.|..|.|...||||::..|.|||:||..:||.:|:|
Human    77 KQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSE 141

  Fly   143 KHARFYAAQVALALEYMHKMHLMYRDLKPENILLDQRGYIKITDFGFTKRVDGRTSTLCGTPEYL 207
            .||.||||||.||::|:|.:.|::|||||||:|:||:||:::|||||.|||.|||.|||||||||
Human   142 PHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKGRTWTLCGTPEYL 206

  Fly   208 APEIVQLRPYNKSVDWWAFGILVYEFVAGRSPFAIHNRDVILMYSKICICDYKMPSYFTSQLRSL 272
            ||||:..:.|||:|||||.|:|:||...|..||  :....|.:|.||.....:.||..:|.|:.|
Human   207 APEIILSKGYNKAVDWWALGVLIYEMAVGFPPF--YADQPIQIYEKIVSGRVRFPSKLSSDLKHL 269

  Fly   273 VESLMQVDTSKRLGNSNDGSSDVKSHPWFQGVDWFGILNQEVTAPYQPTISGAEDLSNFENFEFK 337
            :.||:|||.:||.||..:|..|:|:|.||....|..|..::|.||:.|..:|..|.|||:::| :
Human   270 LRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNFDDYE-E 333

  Fly   338 DRYKSRIN 345
            :..:..||
Human   334 EELRISIN 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C2	NP_733397.2	Protein Kinases, catalytic domain	43..334	CDD:473864	145/290 (50%)
PRKACG	NP_002723.2	STKc_PKA	42..331	CDD:271111	145/290 (50%)