Protein Alignment Pka-C2 and PRKACA

DIOPT Version :9

• Sequence 1: NP_733397.2
• Gene: Pka-C2 / 43644
• FlyBaseID: FBgn0000274
• Length: 354
• Species: Drosophila melanogaster
• Sequence 2: NP_001291278.1
• Gene: PRKACA / 5566
• HGNCID: 9380
• Length: 427
• Species: Homo sapiens
• Alignment Length: 333
• Identity: 157/333 - (47%)
• Similarity: 224/333 - (67%)
• Gaps: 7/333 - (2%)

  Fly    16 YNVILDNMSR---EFEERWNHQTQSPYTNLENYITRAVLGNGSFGTVMLVREKSGKNYYAAKMMS 77
            :||:.:.:::   :|.::|....|:. .:|:.:.....||.||||.||||:.|...|:||.|::.
Human    89 WNVVKEFLAKAKEDFLKKWESPAQNT-AHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILD 152

  Fly    78 KEDLVRLKQVAHVHNEKHVLNAARFPFLIYLVDSTKCFDYLYLILPLVNGGELFSYHRRVRKFNE 142
            |:.:|:|||:.|..|||.:|.|..||||:.|..|.|....||:::..|.|||:||:.||:.:|:|
Human   153 KQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSE 217

  Fly   143 KHARFYAAQVALALEYMHKMHLMYRDLKPENILLDQRGYIKITDFGFTKRVDGRTSTLCGTPEYL 207
            .||||||||:.|..||:|.:.|:||||||||:|:||:|||::|||||.|||.|||.|||||||||
Human   218 PHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYL 282

  Fly   208 APEIVQLRPYNKSVDWWAFGILVYEFVAGRSPFAIHNRDVILMYSKICICDYKMPSYFTSQLRSL 272
            ||||:..:.|||:|||||.|:|:||..||..||...  ..|.:|.||.....:.||:|:|.|:.|
Human   283 APEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFAD--QPIQIYEKIVSGKVRFPSHFSSDLKDL 345

  Fly   273 VESLMQVDTSKRLGNSNDGSSDVKSHPWFQGVDWFGILNQEVTAPYQPTISGAEDLSNFENFEFK 337
            :.:|:|||.:||.||..:|.:|:|:|.||...||..|..::|.||:.|...|..|.|||:::| :
Human   346 LRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYE-E 409

  Fly   338 DRYKSRIN 345
            :..:..||
Human   410 EEIRVSIN 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C2	NP_733397.2	PKc_like	43..334	CDD:328722	148/290 (51%)
PRKACA	NP_001291278.1	STKc_PKA	118..407	CDD:271111	148/290 (51%)
		S_TKc	120..374	CDD:214567	134/255 (53%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142886
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0616
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S234
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D277423at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24353
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.760