DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pka-C2 and prkg1a

DIOPT Version :9

Sequence 1:	NP_733397.2	Gene:	Pka-C2 / 43644	FlyBaseID:	FBgn0000274	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	XP_005157115.1	Gene:	prkg1a / 394005	ZFINID:	ZDB-GENE-040426-1308	Length:	684	Species:	Danio rerio

Alignment Length:	327	Identity:	114/327 - (34%)
Similarity:	186/327 - (56%)	Gaps:	14/327 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LDNMS----REFEERWNHQTQSPY---TNLENYITRAVLGNGSFGTVMLVREKSGK-NYYAAKMM 76
            |:::|    .:.|.:..::.::.:   .||.::.....||.|.||.|.||:.||.: ..:|.|::
Zfish   341 LEDVSNKGCEDAEAKAKYEAENAFFSNLNLSDFNIIDTLGVGGFGRVELVQLKSDEMKTFAMKIL 405

  Fly    77 SKEDLVRLKQVAHVHNEKHVLNAARFPFLIYLVDSTKCFDYLYLILPLVNGGELFSYHRRVRKFN 141
            .|..:|..:|..|:.:||.::..|...|::.|..:.|...|||:::....||||::..|....|:
Zfish   406 KKRHIVDTRQQEHIRSEKLIMQEAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGNFD 470

  Fly   142 EKHARFYAAQVALALEYMHKMHLMYRDLKPENILLDQRGYIKITDFGFTKRV--DGRTSTLCGTP 204
            :...|||.|.|..|..|:|...::||||||||::||.|||.|:.||||.|::  ..:|.|.||||
Zfish   471 DSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTP 535

  Fly   205 EYLAPEIVQLRPYNKSVDWWAFGILVYEFVAGRSPFAIHNRDVILMYSKIC--ICDYKMPSYFTS 267
            ||:||||:..:.::.|.|:|:.|||:||.:.|..||:  ..|.:..|:.|.  |...:.|...|.
Zfish   536 EYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFS--GPDPMKTYNIILRGIDMIEFPKKITK 598

  Fly   268 QLRSLVESLMQVDTSKRLGNSNDGSSDVKSHPWFQGVDWFGILNQEVTAPYQPTISGAEDLSNFE 332
            ...:|::.|.:...|:||||..:|..|::.|.||:|.:|.|:....:..|..|.::.:.|.|||:
Zfish   599 NAANLIKKLCRDTPSERLGNLKNGVKDIQKHKWFEGFNWDGLRKGTLMPPIIPNVTSSTDTSNFD 663

  Fly   333 NF 334
            :|
Zfish   664 SF 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C2	NP_733397.2	PKc_like	43..334	CDD:328722	108/295 (37%)
prkg1a	XP_005157115.1	DD_cGKI-beta	6..57	CDD:213375
		Crp	114..>264	CDD:223736
		CAP_ED	116..225	CDD:237999
		Crp	228..>332	CDD:223736
		CAP_ED	235..339	CDD:237999
		PTZ00263	355..674	CDD:140289	111/313 (35%)
		STKc_cGK	379..639	CDD:270724	101/261 (39%)
		S_TK_X	634..>677	CDD:214529	10/32 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575730
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840