DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pka-C2 and Akt1

DIOPT Version :10

Sequence 1:NP_733397.2 Gene:Pka-C2 / 43644 FlyBaseID:FBgn0000274 Length:354 Species:Drosophila melanogaster
Sequence 2:NP_150233.1 Gene:Akt1 / 24185 RGDID:2081 Length:480 Species:Rattus norvegicus


Alignment Length:340 Identity:121/340 - (35%)
Similarity:196/340 - (57%) Gaps:25/340 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 ILDNMSREFEERWNHQTQSPYTN------------------LENYITRAVLGNGSFGTVMLVREK 65
            :.|.:.|:.||..:.::.||..|                  :..:....:||.|:||.|:||:||
  Rat   106 VADGLKRQEEETMDFRSGSPSDNSGAEEMEVALAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEK 170

  Fly    66 SGKNYYAAKMMSKEDLVRLKQVAHVHNEKHVLNAARFPFLIYLVDSTKCFDYLYLILPLVNGGEL 130
            :...|||.|::.||.:|...:|||...|..||..:|.|||..|..|.:..|.|..::...|||||
  Rat   171 ATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGEL 235

  Fly   131 FSYHRRVRKFNEKHARFYAAQVALALEYMH-KMHLMYRDLKPENILLDQRGYIKITDFGFTKR-- 192
            |.:..|.|.|:|..||||.|::..||:|:| :.:::|||||.||::||:.|:|||||||..|.  
  Rat   236 FFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI 300

  Fly   193 VDGRT-STLCGTPEYLAPEIVQLRPYNKSVDWWAFGILVYEFVAGRSPFAIHNRDVILMYSKICI 256
            .||.| .|.||||||||||:::...|.::||||..|:::||.:.||.||  :|:|...::..|.:
  Rat   301 KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF--YNQDHEKLFELILM 363

  Fly   257 CDYKMPSYFTSQLRSLVESLMQVDTSKRLGNSNDGSSDVKSHPWFQGVDWFGILNQEVTAPYQPT 321
            .:.:.|.....:.:||:..|::.|.::|||..::.:.::..|.:|..:.|..:..::::.|::|.
  Rat   364 EEIRFPRTLGPEAKSLLSGLLKKDPTQRLGGGSEDAKEIMQHRFFANIVWQDVYEKKLSPPFKPQ 428

  Fly   322 ISGAEDLSNFENFEF 336
            ::...|...|:. ||
  Rat   429 VTSETDTRYFDE-EF 442

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pka-C2NP_733397.2 Protein Kinases, catalytic domain 43..334 CDD:473864 112/294 (38%)
Akt1NP_150233.1 PH_PKB 4..111 CDD:269947 1/4 (25%)
STKc_PKB_alpha 124..479 CDD:270746 117/322 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 451..480
Blue background indicates that the domain is not in the aligned region.

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