Protein Alignment Pka-C2 and AKT2

DIOPT Version :10

• Sequence 1: NP_733397.2
• Gene: Pka-C2 / 43644
• FlyBaseID: FBgn0000274
• Length: 354
• Species: Drosophila melanogaster
• Sequence 2: NP_001617.1
• Gene: AKT2 / 208
• HGNCID: 392
• Length: 481
• Species: Homo sapiens
• Alignment Length: 305
• Identity: 118/305 - (38%)
• Similarity: 182/305 - (59%)
• Gaps: 15/305 - (4%)

  Fly    50 VLGNGSFGTVMLVREKSGKNYYAAKMMSKEDLVRLKQVAHVHNEKHVLNAARFPFLIYLVDSTKC 114
            :||.|:||.|:|||||:...|||.|::.||.::...:|||...|..||...|.|||..|..:.:.
Human   157 LLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQT 221

  Fly   115 FDYLYLILPLVNGGELFSYHRRVRKFNEKHARFYAAQVALALEYMHKMHLMYRDLKPENILLDQR 179
            .|.|..::...||||||.:..|.|.|.|:.||||.|::..||||:|...::|||:|.||::||:.
Human   222 HDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKD 286

  Fly   180 GYIKITDFGFTKR--VDGRT-STLCGTPEYLAPEIVQLRPYNKSVDWWAFGILVYEFVAGRSPFA 241
            |:|||||||..|.  .||.| .|.||||||||||:::...|.::||||..|:::||.:.||.||
Human   287 GHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF- 350

  Fly   242 IHNRDVILMYSKICICDYKMPSYFTSQLRSLVESLMQVDTSKRLGNSNDGSSDVKSHPWFQGVDW 306
             :|:|...::..|.:.:.:.|...:.:.:||:..|::.|..:|||.....:.:|..|.:|..::|
Human   351 -YNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINW 414

  Fly   307 FGILNQEVTAPYQPTISGAEDLSNFENFEF---------KDRYKS 342
            ..::.:::..|::|.::...|...|:: ||         .|||.|
Human   415 QDVVQKKLLPPFKPQVTSEVDTRYFDD-EFTAQSITITPPDRYDS 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C2	NP_733397.2	Protein Kinases, catalytic domain	43..334	CDD:473864	112/286 (39%)
AKT2	NP_001617.1	PH_PKB	4..111	CDD:269947
		STKc_PKB_beta	156..478	CDD:173686	118/305 (39%)