DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pka-C2 and Prkg2

DIOPT Version :9

Sequence 1:	NP_733397.2	Gene:	Pka-C2 / 43644	FlyBaseID:	FBgn0000274	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_032952.3	Gene:	Prkg2 / 19092	MGIID:	108173	Length:	762	Species:	Mus musculus

Alignment Length:	302	Identity:	116/302 - (38%)
Similarity:	180/302 - (59%)	Gaps:	9/302 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SPYTNLENYITRAVLGNGSFGTVMLVREKSGKNYYAAKMMSKEDLVRLKQVAHVHNEKHVLNAAR 101
            ||:.|||   ..|.||.|.||.|.||:.|:....:|.|.:.|:.:|..||..||::||.:|....
Mouse   448 SPFQNLE---IIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELC 509

  Fly   102 FPFLIYLVDSTKCFDYLYLILPLVNGGELFSYHRRVRKFNEKHARFYAAQVALALEYMHKMHLMY 166
            .||::.|..:.|...|:|::|....||||:|..|....|:|..::|..|.|..|.:|:|::.::|
Mouse   510 SPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIY 574

  Fly   167 RDLKPENILLDQRGYIKITDFGFTKRVDG--RTSTLCGTPEYLAPEIVQLRPYNKSVDWWAFGIL 229
            |||||||::||..||:|:.||||.|::..  :|.|.||||||:|||::..:.::.|||:|:.|||
Mouse   575 RDLKPENLILDADGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGIL 639

  Fly   230 VYEFVAGRSPFAIHNRDVILMYSKICICDYKM--PSYFTSQLRSLVESLMQVDTSKRLGNSNDGS 292
            |||.:.|..||:  ..|.::.|:.|.....||  |...|.:...|:..|.:.:.::||||..:|.
Mouse   640 VYELLTGNPPFS--GIDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGI 702

  Fly   293 SDVKSHPWFQGVDWFGILNQEVTAPYQPTISGAEDLSNFENF 334
            :|:|.|.|..|.:|.|:..:.:.:|.:..:||..|.|.|:.:
Mouse   703 NDIKKHRWLNGFNWEGLKARSLPSPLRRELSGPIDHSYFDKY 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C2	NP_733397.2	PKc_like	43..334	CDD:328722	112/294 (38%)
Prkg2	NP_032952.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	118..138
		Crp	162..>285	CDD:223736
		cGMP-binding, high affinity, cAMP-binding, moderate affinity. /evidence=ECO:0000250\|UniProtKB:Q13237	168..283
		CAP_ED	168..273	CDD:237999
		cGMP-binding, high affinity, cAMP-binding, low affinity. /evidence=ECO:0000250\|UniProtKB:Q13237	286..416
		CAP_ED	286..401	CDD:237999
		PTZ00263	417..752	CDD:140289	116/302 (38%)
		STKc_cGK	459..718	CDD:270724	103/260 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	740..762		1/5 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833013
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840