Protein Alignment Pka-C2 and Prkg1

DIOPT Version :10

• Sequence 1: NP_733397.2
• Gene: Pka-C2 / 43644
• FlyBaseID: FBgn0000274
• Length: 354
• Species: Drosophila melanogaster
• Sequence 2: NP_035290.1
• Gene: Prkg1 / 19091
• MGIID: 108174
• Length: 686
• Species: Mus musculus
• Alignment Length: 327
• Identity: 114/327 - (34%)
• Similarity: 186/327 - (56%)
• Gaps: 14/327 - (4%)

  Fly    20 LDNMS----REFEERWNHQTQSPY---TNLENYITRAVLGNGSFGTVMLVREKSGKN-YYAAKMM 76
            ||::|    .:.|.:..::.::.:   ..|.::.....||.|.||.|.||:.||.:: .:|.|::
Mouse   343 LDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKIL 407

  Fly    77 SKEDLVRLKQVAHVHNEKHVLNAARFPFLIYLVDSTKCFDYLYLILPLVNGGELFSYHRRVRKFN 141
            .|..:|..:|..|:.:||.::..|...|::.|..:.|...|||:::....||||::..|....|.
Mouse   408 KKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFE 472

  Fly   142 EKHARFYAAQVALALEYMHKMHLMYRDLKPENILLDQRGYIKITDFGFTKRV--DGRTSTLCGTP 204
            :...|||.|.|..|..|:|...::||||||||::||.|||.|:.||||.|::  ..:|.|.||||
Mouse   473 DSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTP 537

  Fly   205 EYLAPEIVQLRPYNKSVDWWAFGILVYEFVAGRSPFAIHNRDVILMYSKIC--ICDYKMPSYFTS 267
            ||:||||:..:.::.|.|:|:.|||:||.:.|..||:  ..|.:..|:.|.  |...:.|.....
Mouse   538 EYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFS--GPDPMKTYNIILRGIDMIEFPKKIAK 600

  Fly   268 QLRSLVESLMQVDTSKRLGNSNDGSSDVKSHPWFQGVDWFGILNQEVTAPYQPTISGAEDLSNFE 332
            ...:|::.|.:.:.|:||||..:|..|::.|.||:|.:|.|:....:|.|..|:::...|.|||:
Mouse   601 NAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFD 665

  Fly   333 NF 334
            :|
Mouse   666 SF 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C2	NP_733397.2	Protein Kinases, catalytic domain	43..334	CDD:473864	108/295 (37%)
Prkg1	NP_035290.1	DD_cGKI-beta	4..55	CDD:213375
		CAP_ED	118..227	CDD:237999
		CAP_ED	237..341	CDD:237999
		STKc_cGK	381..641	CDD:270724	100/261 (38%)
		S_TK_X	636..>679	CDD:214529	11/32 (34%)