Protein Alignment Pka-C2 and STK38

DIOPT Version :10

• Sequence 1: NP_733397.2
• Gene: Pka-C2 / 43644
• FlyBaseID: FBgn0000274
• Length: 354
• Species: Drosophila melanogaster
• Sequence 2: NP_009202.1
• Gene: STK38 / 11329
• HGNCID: 17847
• Length: 465
• Species: Homo sapiens
• Alignment Length: 463
• Identity: 116/463 - (25%)
• Similarity: 195/463 - (42%)
• Gaps: 140/463 - (30%)

  Fly     1 MSQHTSQYVFNSKEDYNVILDNMSREFEERWNHQ-------------------TQSPYT------ 40
            ||.||.:.|..:|........|:..:.|||...|                   .:|.:.
Human    12 MSNHTKERVTMTKVTLENFYSNLIAQHEEREMRQKKLEKVMEEEGLKDEEKRLRRSAHARKETEF 76

  Fly    41 --------NLENYITRAVLGNGSFGTVMLVREKSGKNYYAAKMMSKEDLVRLKQVAHVHNEKHVL 97
                    .||::.:..|:|.|:||.|.||::|...:.||.|::.|.|::..:||.|:..|:.:|
Human    77 LRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDIL 141

  Fly    98 NAARFPFLIYLVDSTKCFDYLYLILPLVNGGELFSYHRRVRKFNEKHARFYAAQVALALEYMHKM 162
            ..|...:::.:..|.:....||||:..:.||::.:...:.....|:..:||.|:..||::.:|::
Human   142 VEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQL 206

  Fly   163 HLMYRDLKPENILLDQRGYIKITDFG------------------------FT------------- 190
            ..::||:||:|:|||.:|::|::|||                        ||
Human   207 GFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETW 271

  Fly   191 --KRVDGRTSTLCGTPEYLAPEIVQLRPYNKSVDWWAFGILVYEFVAGRSPFAIHN--------- 244
              .|.....||: |||:|:|||:.....|||..|||:.|:::||.:.|..||....
Human   272 KRNRRQLAFSTV-GTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVM 335

  Fly   245 ------------------RDVILMYSKICICDYKMPSYFTSQLRSLVESLMQVDTSKRLGNSNDG 291
                              :|:||   :.| |:::                      .|:|  ..|
Human   336 NWKETLTFPPEVPISEKAKDLIL---RFC-CEWE----------------------HRIG--APG 372

  Fly   292 SSDVKSHPWFQGVDWFGILNQEVTAPYQPTISGAEDLSNFENFEFKDRYKSRI--NRHPE----- 349
            ..::||:.:|:||||..|  :|..|.....|...:|.|||:.|...|..|..:  :.|||
Human   373 VEEIKSNSFFEGVDWEHI--RERPAAISIEIKSIDDTSNFDEFPESDILKPTVATSNHPETDYKN 435

  Fly   350 ---LFANF 354
               :|.|:
Human   436 KDWVFINY 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C2	NP_733397.2	Protein Kinases, catalytic domain	43..334	CDD:473864	95/356 (27%)
STK38	NP_009202.1	MobB_NDR1	11..85	CDD:439276	12/72 (17%)
		Interaction with S100B. /evidence=ECO:0000269|PubMed:14661952	62..87		1/24 (4%)
		STKc_NDR1	87..462	CDD:270777	103/388 (27%)
		UFM1-interacting motif (UFIM). /evidence=ECO:0000269|PubMed:32537488	306..311		2/4 (50%)