Protein Alignment CG12069 and AURKA

DIOPT Version :10

• Sequence 1: NP_651819.1
• Gene: CG12069 / 43643
• FlyBaseID: FBgn0039796
• Length: 356
• Species: Drosophila melanogaster
• Sequence 2: NP_001411347.1
• Gene: AURKA / 6790
• HGNCID: 11393
• Length: 437
• Species: Homo sapiens
• Alignment Length: 289
• Identity: 93/289 - (32%)
• Similarity: 147/289 - (50%)
• Gaps: 19/289 - (6%)

  Fly    44 LDDYEIKATLGSGSFGKVQLVRERESGVYYASKQLSKDQIVKTKQVSHVMSEKNVLRSMTFPNTV 108
            |:|:||...||.|.||.|.|.||::|....|.|.|.|.|:.|......:..|..:...:..||.:
Human   164 LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNIL 228

  Fly   109 NLIASYKDFDSLYLVLPLIGGGELFTYHRKVRKFTEKQARFYAAQVFLALEYLHHCSLLYRDLKP 173
            .|...:.|...:||:|.....|.::...:|:.||.|::...|..::..||.|.|...:::||:||
Human   229 RLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKP 293

  Fly   174 ENIMMDKNGYLKVTDFGFAKKV-ETRTMTLCGTPEYLPPEIIQSKPYGTSVDWWAFGVLVFEFVA 237
            ||:::...|.||:.|||::... .:|..|||||.:|||||:|:.:.:...||.|:.|||.:||:.
Human   294 ENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLV 358

  Fly   238 GHSPFSAHNRDVMSMYNKICEADYKMPSYFSGALRHLVDHLLQVDLSKRFGNLINGNRDIKEHEW 302
            |..||.|:.  ....|.:|...::..|.:.:...|.|:..||:.:.|:|  .::   |::.||.|
Human   359 GKPPFEANT--YQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQR--PML---REVLEHPW 416

  Fly   303 FKDVEWIPLLNQTVNAPYVPNISNPEDIS 331
            .           |.|:....|..|.|..|
Human   417 I-----------TANSSKPSNCQNKESAS 434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12069	NP_651819.1	Protein Kinases, catalytic domain	45..335	CDD:473864	92/288 (32%)
AURKA	NP_001411347.1	STKc_Aurora-A	161..418	CDD:271018	87/271 (32%)