Protein Alignment CG12069 and SGK1

DIOPT Version :10

• Sequence 1: NP_651819.1
• Gene: CG12069 / 43643
• FlyBaseID: FBgn0039796
• Length: 356
• Species: Drosophila melanogaster
• Sequence 2: NP_001137148.1
• Gene: SGK1 / 6446
• HGNCID: 10810
• Length: 526
• Species: Homo sapiens
• Alignment Length: 373
• Identity: 139/373 - (37%)
• Similarity: 211/373 - (56%)
• Gaps: 33/373 - (8%)

  Fly    14 PKVDYILILDKLRE-DFNKKFATNTPSPSTGLD------------DYEIKATLGSGSFGKVQLVR 65
            |:|..||.:.:.:| :......:..||||..::            |:.....:|.||||||.|.|
Human   147 PEVQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLAR 211

  Fly    66 ERESGVYYASKQLSKDQIVKTKQVSHVMSEKNV-LRSMTFPNTVNLIASYKDFDSLYLVLPLIGG 129
            .:...|:||.|.|.|..|:|.|:..|:|||:|| |:::..|..|.|..|::..|.||.||..|.|
Human   212 HKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYING 276

  Fly   130 GELFTYHRKVRKFTEKQARFYAAQVFLALEYLHHCSLLYRDLKPENIMMDKNGYLKVTDFGFAKK 194
            ||||.:.::.|.|.|.:||||||::..||.|||..:::|||||||||::|..|::.:||||..|:
Human   277 GELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKE 341

  Fly   195 -VE--TRTMTLCGTPEYLPPEIIQSKPYGTSVDWWAFGVLVFEFVAGHSPFSAHNRDVMSMYNKI 256
             :|  :.|.|.|||||||.||::..:||..:||||..|.:::|.:.|..||  ::|:...||:.|
Human   342 NIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPF--YSRNTAEMYDNI 404

  Fly   257 CEADYKMPSYFSGALRHLVDHLLQVDLSKRFGNLINGNRDIKEHEWFKDVEWIPLLNQTVNAPYV 321
            .....::....:.:.|||::.|||.|.:||.| ..:...:||.|.:|..:.|..|:|:.:..|:.
Human   405 LNKPLQLKPNITNSARHLLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFN 468

  Fly   322 PNISNPEDISNFD-KVSDKPRPK------------AKTMRHEEAFADF 356
            ||:|.|.|:.:|| :.:::|.|.            |......|||..|
Human   469 PNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGF 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12069	NP_651819.1	Protein Kinases, catalytic domain	45..335	CDD:473864	123/306 (40%)
SGK1	NP_001137148.1	STKc_SGK	197..519	CDD:270727	129/323 (40%)