Protein Alignment CG12069 and RPS6KB1

DIOPT Version :10

• Sequence 1: NP_651819.1
• Gene: CG12069 / 43643
• FlyBaseID: FBgn0039796
• Length: 356
• Species: Drosophila melanogaster
• Sequence 2: NP_003152.1
• Gene: RPS6KB1 / 6198
• HGNCID: 10436
• Length: 525
• Species: Homo sapiens
• Alignment Length: 324
• Identity: 111/324 - (34%)
• Similarity: 176/324 - (54%)
• Gaps: 14/324 - (4%)

  Fly    31 KKFATNTPSPSTGLDD-----YEIKATLGSGSFGKVQLVRE---RESGVYYASKQLSKDQIVK-T 86
            :||..:..|.:.|.:.     :|:...||.|.:|||..||:   ..:|..:|.|.|.|..||: .
Human    70 EKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNA 134

  Fly    87 KQVSHVMSEKNVLRSMTFPNTVNLIASYKDFDSLYLVLPLIGGGELFTYHRKVRKFTEKQARFYA 151
            |..:|..:|:|:|..:..|..|:||.:::....|||:|..:.|||||....:...|.|..|.||.
Human   135 KDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYL 199

  Fly   152 AQVFLALEYLHHCSLLYRDLKPENIMMDKNGYLKVTDFGFAKKV---ETRTMTLCGTPEYLPPEI 213
            |::.:||.:||...::||||||||||::..|::|:||||..|:.   .|.|.|.|||.||:.|||
Human   200 AEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEI 264

  Fly   214 IQSKPYGTSVDWWAFGVLVFEFVAGHSPFSAHNRDVMSMYNKICEADYKMPSYFSGALRHLVDHL 278
            :....:..:||||:.|.|:::.:.|..||:..||  ....:||.:....:|.|.:...|.|:..|
Human   265 LMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENR--KKTIDKILKCKLNLPPYLTQEARDLLKKL 327

  Fly   279 LQVDLSKRFGNLINGNRDIKEHEWFKDVEWIPLLNQTVNAPYVPNISNPEDISNFDKVSDKPRP 342
            |:.:.:.|.|.......:::.|.:|:.:.|..||.:.|..|:.|.:.:.||:|.||....:..|
Human   328 LKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTP 391

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12069	NP_651819.1	Protein Kinases, catalytic domain	45..335	CDD:473864	105/301 (35%)
RPS6KB1	NP_003152.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..54
		TOS motif	28..32
		STKc_p70S6K	94..416	CDD:270736	106/300 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	380..399		4/12 (33%)
		Autoinhibitory domain	424..525