Protein Alignment CG12069 and RPS6KA1

DIOPT Version :10

• Sequence 1: NP_651819.1
• Gene: CG12069 / 43643
• FlyBaseID: FBgn0039796
• Length: 356
• Species: Drosophila melanogaster
• Sequence 2: NP_001006666.1
• Gene: RPS6KA1 / 6195
• HGNCID: 10430
• Length: 744
• Species: Homo sapiens
• Alignment Length: 354
• Identity: 116/354 - (32%)
• Similarity: 190/354 - (53%)
• Gaps: 35/354 - (9%)

  Fly     2 GPQPEQAQMHFSPKVDYILILDKLREDFNKKFATNTPSPSTGLDDYEIKATLGSGSFGKVQLVRE 66
            |||.:..:.          :|.::....:.|..:....||    .:|:...||.||||||.|||:
Human    40 GPQRDSDEG----------VLKEISITHHVKAGSEKADPS----HFELLKVLGQGSFGKVFLVRK 90

  Fly    67 ---RESGVYYASKQLSKDQI-----VKTKQVSHVMSEKNVLRSMTFPNTVNLIASYKDFDSLYLV 123
               .:||..||.|.|.|..:     |:||.      |:::|..:..|..|.|..:::....|||:
Human    91 VTRPDSGHLYAMKVLKKATLKVRDRVRTKM------ERDILADVNHPFVVKLHYAFQTEGKLYLI 149

  Fly   124 LPLIGGGELFTYHRKVRKFTEKQARFYAAQVFLALEYLHHCSLLYRDLKPENIMMDKNGYLKVTD 188
            |..:.||:|||...|...|||:..:||.|::.|.|::||...::|||||||||::|:.|::|:||
Human   150 LDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTD 214

  Fly   189 FGFAKKV---ETRTMTLCGTPEYLPPEIIQSKPYGTSVDWWAFGVLVFEFVAGHSPFSAHNR-DV 249
            ||.:|:.   |.:..:.|||.||:.||::..:.:..|.|||::|||:||.:.|..||...:| :.
Human   215 FGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKET 279

  Fly   250 MSMYNKICEADYKMPSYFSGALRHLVDHLLQVDLSKRFGNLINGNRDIKEHEWFKDVEWIPLLNQ 314
            |::   |.:|...||.:.|...:.|:..|.:.:.:.|.|:..:|..:||.|.::..::|..|..:
Human   280 MTL---ILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRR 341

  Fly   315 TVNAPYVPNISNPEDISNFDKVSDKPRPK 343
            .:..|:.|.::.|:|...||.......||
Human   342 EIKPPFKPAVAQPDDTFYFDTEFTSRTPK 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12069	NP_651819.1	Protein Kinases, catalytic domain	45..335	CDD:473864	106/301 (35%)
RPS6KA1	NP_001006666.1	STKc_RSK_N	75..391	CDD:270734	108/305 (35%)
		STKc_RSK1_C	425..715	CDD:271077