Protein Alignment CG12069 and PRKX

DIOPT Version :10

• Sequence 1: NP_651819.1
• Gene: CG12069 / 43643
• FlyBaseID: FBgn0039796
• Length: 356
• Species: Drosophila melanogaster
• Sequence 2: NP_005035.1
• Gene: PRKX / 5613
• HGNCID: 9441
• Length: 358
• Species: Homo sapiens
• Alignment Length: 352
• Identity: 135/352 - (38%)
• Similarity: 208/352 - (59%)
• Gaps: 28/352 - (7%)

  Fly    27 EDFNKKFATNTPS----------------PSTGLDDYEIKATLGSGSFGKVQLVRERESGVYYAS 75
            |..::|.|..||.                |...|.|::..||:|:|:||:|.||:|:.:..::|.
Human    13 ESDSRKVAEETPDGAPALCPSPEALSPEPPVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFAL 77

  Fly    76 KQLSKDQIVKTKQVSHVMSEKNVLRSMTFPNTVNLIASYKDFDSLYLVLPLIGGGELFTYHRKVR 140
            |.:|...:::.||..||.:||:||:.::.|..:.|..::.|...||:::..:.|||||:|.|...
Human    78 KVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRG 142

  Fly   141 KFTEKQARFYAAQVFLALEYLHHCSLLYRDLKPENIMMDKNGYLKVTDFGFAKKVETRTMTLCGT 205
            :|:.....||:|::..|:||||...::|||||||||::|::|::|:||||||||:..||.|||||
Human   143 RFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGT 207

  Fly   206 PEYLPPEIIQSKPYGTSVDWWAFGVLVFEFVAGHSPFSAHNRDVMSMYNKICEADYKMPSYFSGA 270
            ||||.||:||||.:|.:|||||.|:|:||.::|..||...|  ...:|.||.......|.:....
Human   208 PEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDN--PFGIYQKILAGKIDFPRHLDFH 270

  Fly   271 LRHLVDHLLQVDLSKRFGNLINGNRDIKEHEWFKDVEWIPLLNQTVNAPYVPNISNPEDISNFDK 335
            ::.|:..||.||.::|.||:.||..|:|.|.||:.|:|..:..:.:..|.||.|:...|.|||:.
Human   271 VKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFET 335

  Fly   336 VSDK------PRPKAKTMRHEEAFADF 356
            ..:.      |.|:    :..|.|.:|
Human   336 YPENDWDTAAPVPQ----KDLEIFKNF 358

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12069	NP_651819.1	Protein Kinases, catalytic domain	45..335	CDD:473864	123/289 (43%)
PRKX	NP_005035.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34		5/20 (25%)
		STKc_PRKX_like	47..338	CDD:270763	123/292 (42%)