Protein Alignment CG12069 and PRKG1

DIOPT Version :10

• Sequence 1: NP_651819.1
• Gene: CG12069 / 43643
• FlyBaseID: FBgn0039796
• Length: 356
• Species: Drosophila melanogaster
• Sequence 2: NP_006249.1
• Gene: PRKG1 / 5592
• HGNCID: 9414
• Length: 686
• Species: Homo sapiens
• Alignment Length: 307
• Identity: 123/307 - (40%)
• Similarity: 178/307 - (57%)
• Gaps: 10/307 - (3%)

  Fly    44 LDDYEIKATLGSGSFGKVQLVR-ERESGVYYASKQLSKDQIVKTKQVSHVMSEKNVLRSMTFPNT 107
            |.|:.|..|||.|.||:|:||: :.|....:|.|.|.|..||.|:|..|:.|||.:::.......
Human   372 LSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFI 436

  Fly   108 VNLIASYKDFDSLYLVLPLIGGGELFTYHRKVRKFTEKQARFYAAQVFLALEYLHHCSLLYRDLK 172
            |.|..::||...||:::....||||:|..|....|.:...|||.|.|..|..|||...::|||||
Human   437 VRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLK 501

  Fly   173 PENIMMDKNGYLKVTDFGFAKKV--ETRTMTLCGTPEYLPPEIIQSKPYGTSVDWWAFGVLVFEF 235
            |||:::|..||.|:.|||||||:  ..:|.|.||||||:.||||.:|.:..|.|:|:.|:|::|.
Human   502 PENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYEL 566

  Fly   236 VAGHSPFSAHNRDVMSMYNKICEA--DYKMPSYFSGALRHLVDHLLQVDLSKRFGNLINGNRDIK 298
            :.|..|||  ..|.|..||.|...  ..:.|...:....:|:..|.:.:.|:|.|||.||.:||:
Human   567 LTGSPPFS--GPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQ 629

  Fly   299 EHEWFKDVEWIPLLNQTVNAPYVPNISNPEDISNFDKV---SDKPRP 342
            :|:||:...|..|...|:..|.:|::::|.|.||||..   :|:|.|
Human   630 KHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPP 676

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12069	NP_651819.1	Protein Kinases, catalytic domain	45..335	CDD:473864	118/294 (40%)
PRKG1	NP_006249.1	DD_cGKI-beta	4..55	CDD:213375
		CAP_ED	118..227	CDD:237999
		CAP_ED	237..341	CDD:237999
		STKc_cGK	381..641	CDD:270724	106/261 (41%)
		S_TK_X	636..>679	CDD:214529	14/41 (34%)