DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG12069 and PKN2

DIOPT Version :10

Sequence 1:NP_651819.1 Gene:CG12069 / 43643 FlyBaseID:FBgn0039796 Length:356 Species:Drosophila melanogaster
Sequence 2:NP_006247.1 Gene:PKN2 / 5586 HGNCID:9406 Length:984 Species:Homo sapiens


Alignment Length:328 Identity:113/328 - (34%)
Similarity:178/328 - (54%) Gaps:19/328 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 LDDYEIKATLGSGSFGKVQLVRERESGVYYASKQLSKDQIVKTKQVSHVMSEKNV---LRSMTFP 105
            |.|:...|.||.|.||||.|...:.:...:|.|.|.|..||...:|..:|.||.:   :.|:..|
Human   654 LQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHP 718

  Fly   106 NTVNLIASYKDFDSLYLVLPLIGGGELFTY-HRKVRKFTEKQARFYAAQVFLALEYLHHCSLLYR 169
            ..|||.|.::..:.:..|:....||:|..: |..|  |:|.:|.||||.|.|.|:|||...::||
Human   719 FLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDV--FSEPRAVFYAACVVLGLQYLHEHKIVYR 781

  Fly   170 DLKPENIMMDKNGYLKVTDFGFAKK---VETRTMTLCGTPEYLPPEIIQSKPYGTSVDWWAFGVL 231
            |||.:|:::|..|::|:.|||..|:   ...||.|.|||||:|.||::....|..:||||..|||
Human   782 DLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVL 846

  Fly   232 VFEFVAGHSPFSAHNRDVMSMYNKICEADYKMPSYFSGALRHLVDHLLQVDLSKRFGNLINGNRD 296
            ::|.:.|.|||...:.:  .:::.|...:.:.|.:.|.....::..||:.:..:|.|.......|
Human   847 IYEMLVGESPFPGDDEE--EVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAED 909

  Fly   297 IKEHEWFKDVEWIPLLNQTVNAPYVPNISNPEDISNFDK--VSDKP------RPKAKTMRHEEAF 353
            :|:|.:|:.::|..|:::.|..|::|.|...||:||||.  .|:.|      .|:..:...:|.|
Human   910 VKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPPREPRILSEEEQEMF 974

  Fly   354 ADF 356
            .||
Human   975 RDF 977

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12069NP_651819.1 Protein Kinases, catalytic domain 45..335 CDD:473864 104/296 (35%)
PKN2NP_006247.1 HR1_PKN_1 42..107 CDD:212012
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 114..133
HR1 130..201 CDD:469609
HR1_PKN2_3 209..282 CDD:212025
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 351..383
Necessary to rescue apical junction formation. /evidence=ECO:0000250 382..463
C2_PKN-like 390..473 CDD:176069
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 558..584
STKc_PKN 657..982 CDD:270741 111/325 (34%)
Necessary for the catalytic activity 917..977 17/59 (29%)
Negatively regulates the responsiveness of the catalytic activity by cardiolipin and is required for optimal activation by the GTP-bound RhoA 978..984 113/328 (34%)
Blue background indicates that the domain is not in the aligned region.

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