DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG12069 and PRKCI

DIOPT Version :10

Sequence 1:NP_651819.1 Gene:CG12069 / 43643 FlyBaseID:FBgn0039796 Length:356 Species:Drosophila melanogaster
Sequence 2:NP_002731.4 Gene:PRKCI / 5584 HGNCID:9404 Length:596 Species:Homo sapiens


Alignment Length:354 Identity:122/354 - (34%)
Similarity:196/354 - (55%) Gaps:29/354 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 EQAQMHFSPKVDYIL--------ILDKLREDFNKKFATNT-----PSPSTGLDDYEIKATLGSGS 57
            :|:.|| |.....::        .||::.|:   |.|.||     .|.|.||.|:::...:|.||
Human   204 DQSSMH-SDHAQTVIPYNPSSHESLDQVGEE---KEAMNTRESGKASSSLGLQDFDLLRVIGRGS 264

  Fly    58 FGKVQLVRERESGVYYASKQLSKDQIVKTKQVSHVMSEKNVL-RSMTFPNTVNLIASYKDFDSLY 121
            :.||.|||.:::...||.|.:.|:.:...:.:..|.:||:|. ::...|..|.|.:.::....|:
Human   265 YAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLF 329

  Fly   122 LVLPLIGGGELFTYHRKVRKFTEKQARFYAAQVFLALEYLHHCSLLYRDLKPENIMMDKNGYLKV 186
            .|:..:.||:|..:.::.||..|:.||||:|::.|||.|||...::|||||.:|:::|..|::|:
Human   330 FVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKL 394

  Fly   187 TDFGFAK---KVETRTMTLCGTPEYLPPEIIQSKPYGTSVDWWAFGVLVFEFVAGHSPF----SA 244
            ||:|..|   :....|.|.||||.|:.|||::.:.||.||||||.|||:||.:||.|||    |:
Human   395 TDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSS 459

  Fly   245 HNRDVMS---MYNKICEADYKMPSYFSGALRHLVDHLLQVDLSKRFG-NLINGNRDIKEHEWFKD 305
            .|.|..:   ::..|.|...::|...|.....::...|..|..:|.| :...|..||:.|.:|::
Human   460 DNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRN 524

  Fly   306 VEWIPLLNQTVNAPYVPNISNPEDISNFD 334
            |:|..:..:.|..|:.||||....:.|||
Human   525 VDWDMMEQKQVVPPFKPNISGEFGLDNFD 553

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12069NP_651819.1 Protein Kinases, catalytic domain 45..335 CDD:473864 107/302 (35%)
PRKCINP_002731.4 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
Regulatory domain 2..253 15/52 (29%)
Required for interaction with RAB2 2..28
PB1_aPKC 26..108 CDD:99725
Interaction with PARD6A 72..91
Pseudosubstrate. /evidence=ECO:0000250 125..134
C1_aPKC 139..193 CDD:410344
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 220..246 7/28 (25%)
STKc_aPKC_iota 233..596 CDD:270769 115/324 (35%)
Blue background indicates that the domain is not in the aligned region.

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