Protein Alignment CG12069 and PRKCB

DIOPT Version :10

• Sequence 1: NP_651819.1
• Gene: CG12069 / 43643
• FlyBaseID: FBgn0039796
• Length: 356
• Species: Drosophila melanogaster
• Sequence 2: NP_002729.2
• Gene: PRKCB / 5579
• HGNCID: 9395
• Length: 673
• Species: Homo sapiens
• Alignment Length: 345
• Identity: 118/345 - (34%)
• Similarity: 175/345 - (50%)
• Gaps: 30/345 - (8%)

  Fly    23 DKLREDFNK-------------------KFATNTPSPSTGLDDYEIKATLGSGSFGKVQLVRERE 68
            ::||:.|.:                   ||..|.......|.|:.....||.||||||.|...:.
Human   299 EELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKG 363

  Fly    69 SGVYYASKQLSKDQIVKTKQVSHVMSEKNVLRSMTFPNTVNLIAS-YKDFDSLYLVLPLIGGGEL 132
            :...||.|.|.||.:::...|...|.||.||.....|..:..:.| ::..|.||.|:..:.||:|
Human   364 TDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDL 428

  Fly   133 FTYHRKVRKFTEKQARFYAAQVFLALEYLHHCSLLYRDLKPENIMMDKNGYLKVTDFGFAKK--- 194
            ..:.::|.:|.|..|.||||::.:.|.:|....::|||||.:|:|:|..|::|:.|||..|:
Human   429 MYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIW 493

  Fly   195 --VETRTMTLCGTPEYLPPEIIQSKPYGTSVDWWAFGVLVFEFVAGHSPFSAHNRDVMSMYNKIC 257
              |.|:  |.||||:|:.||||..:|||.||||||||||::|.:||.:||...:.|  .::..|.
Human   494 DGVTTK--TFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDED--ELFQSIM 554

  Fly   258 EADYKMPSYFSGALRHLVDHLLQVDLSKRFGNLINGNRDIKEHEWFKDVEWIPLLNQTVNAPYVP 322
            |.:...|...|.....:...|:.....||.|....|.||||||.:|:.::|..|..:.:..||.|
Human   555 EHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKP 619

  Fly   323 NISNPEDISNFDKVSDKPRP 342
            .... .:..|||:...:..|
Human   620 KACG-RNAENFDRFFTRHPP 638

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12069	NP_651819.1	Protein Kinases, catalytic domain	45..335	CDD:473864	109/295 (37%)
PRKCB	NP_002729.2	C1_cPKC_rpt1	35..92	CDD:410383
		C1_cPKC_rpt2	102..155	CDD:410386
		C2_PKC_alpha_gamma	159..289	CDD:175992
		STKc_cPKC_beta	341..663	CDD:270767	111/303 (37%)