Protein Alignment CG12069 and PRKACG

DIOPT Version :10

• Sequence 1: NP_651819.1
• Gene: CG12069 / 43643
• FlyBaseID: FBgn0039796
• Length: 356
• Species: Drosophila melanogaster
• Sequence 2: NP_002723.2
• Gene: PRKACG / 5568
• HGNCID: 9382
• Length: 351
• Species: Homo sapiens
• Alignment Length: 359
• Identity: 167/359 - (46%)
• Similarity: 228/359 - (63%)
• Gaps: 11/359 - (3%)

  Fly     1 MGPQPEQAQMHFSPKVDYILILDKLREDFNKKF---ATNTPSPSTGLDDYEIKATLGSGSFGKVQ 62
            ||..|.:........|:..|.  |.|.||..::   |.||.|.    |.:|...|||.||||:|.
Human     1 MGNAPAKKDTEQEESVNEFLA--KARGDFLYRWGNPAQNTASS----DQFERLRTLGMGSFGRVM 59

  Fly    63 LVRERESGVYYASKQLSKDQIVKTKQVSHVMSEKNVLRSMTFPNTVNLIASYKDFDSLYLVLPLI 127
            |||.:|:|.:||.|.|:|.::||.|||.|:::||.:|:::.||..|.|..|:||...||||:..:
Human    60 LVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLVMEYV 124

  Fly   128 GGGELFTYHRKVRKFTEKQARFYAAQVFLALEYLHHCSLLYRDLKPENIMMDKNGYLKVTDFGFA 192
            .|||:|:..::|.:|:|..|.||||||.||::|||...|::|||||||:::|:.|||:|||||||
Human   125 PGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFA 189

  Fly   193 KKVETRTMTLCGTPEYLPPEIIQSKPYGTSVDWWAFGVLVFEFVAGHSPFSAHNRDVMSMYNKIC 257
            |:|:.||.|||||||||.||||.||.|..:|||||.|||::|...|..||.|.  ..:.:|.||.
Human   190 KRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFYAD--QPIQIYEKIV 252

  Fly   258 EADYKMPSYFSGALRHLVDHLLQVDLSKRFGNLINGNRDIKEHEWFKDVEWIPLLNQTVNAPYVP 322
            ....:.||..|..|:||:..||||||:||||||.||..|||.|:||....||.:..:.|.||::|
Human   253 SGRVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIP 317

  Fly   323 NISNPEDISNFDKVSDKPRPKAKTMRHEEAFADF 356
            ..:.|.|.||||...::....:...:..:.|::|
Human   318 KYTGPGDASNFDDYEEEELRISINEKCAKEFSEF 351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12069	NP_651819.1	Protein Kinases, catalytic domain	45..335	CDD:473864	151/289 (52%)
PRKACG	NP_002723.2	STKc_PKA	42..331	CDD:271111	152/290 (52%)