DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12069 and prkg3

DIOPT Version :9

Sequence 1:	NP_651819.1	Gene:	CG12069 / 43643	FlyBaseID:	FBgn0039796	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	XP_017208033.2	Gene:	prkg3 / 326020	ZFINID:	ZDB-GENE-030131-4745	Length:	745	Species:	Danio rerio

Alignment Length:	346	Identity:	123/346 - (35%)
Similarity:	186/346 - (53%)	Gaps:	25/346 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 KLREDFNKKFATNTPS---PSTGLDDYEI-------------KATLGSGSFGKVQLVRERESGVY 72
            :|.:|.|.......|.   |.|.|...::             ..|||.|.||||:||...|...|
Zfish   399 ELHDDANVSEIDEKPEKARPETSLKLKDLVPVLYQEGSYQGDPVTLGIGGFGKVELVTTLEHRKY 463

  Fly    73 YASKQLSKDQIVKTKQVSHVMSEKNVLRSMTFPNTVNLIASYKDFDSLYLVLPLIGGGELFTYHR 137
            :|.|::||..:|..||.:|::.||.:|:::.....|.|.|::||...:|:::....|||::|..:
Zfish   464 FAMKRISKQHVVAKKQEAHILLEKKILQAIRCDFIVRLHAAFKDSRYVYMIMEFCPGGEIWTKLK 528

  Fly   138 KVRKFTEKQARFYAAQVFLALEYLHHCSLLYRDLKPENIMMDKNGYLKVTDFGFAKKVE--TRTM 200
            :..:|.||.|.|..|.|..|..|||:..:|||||||||:|:|..||:|:.||||||::.  .:|.
Zfish   529 EAGRFEEKIAVFITACVVEAYAYLHNKGILYRDLKPENLMLDSKGYVKLVDFGFAKELSRGEKTY 593

  Fly   201 TLCGTPEYLPPEIIQSKPYGTSVDWWAFGVLVFEFVAGHSPFSAHNRDVMSMYNKICEADYKMPS 265
            :.||||||:.|||||::.:..:.|:|:.|||::|.:.|..|||  :.:...:|.||.:.....||
Zfish   594 SFCGTPEYISPEIIQNQGHDIAADFWSLGVLIYELLVGSPPFS--SSEPQKIYAKILDGVLNFPS 656

  Fly   266 YFSGALRHLVDHLLQVDLSKRFGNLINGNRDIKEHEWFKDVEWIPLLNQTVNAPYVPNISNPEDI 330
            |.....:.::..|.::...:|.||..||.:|::.|.||..:.|..|....:.||.|..|......
Zfish   657 YMGEGAKSIISKLCRLRPGQRLGNTKNGIKDVRHHRWFNSINWHKLRMGQLEAPTVRLIRKGPCY 721

  Fly   331 SNFDKVSDKPRPKAKTMRHEE 351
            .|||:.     |..||...||
Zfish   722 INFDRF-----PYDKTQAEEE 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12069	NP_651819.1	PTZ00263	44..356	CDD:140289	117/323 (36%)
CG12069	NP_651819.1	PKc_like	45..335	CDD:304357	110/304 (36%)
prkg3	XP_017208033.2	CAP_ED	173..282	CDD:237999
		CAP_ED	292..393	CDD:237999
		STKc_cGK	444..699	CDD:270724	101/256 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575724
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840