DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12069 and Prkg2

DIOPT Version :9

Sequence 1:	NP_651819.1	Gene:	CG12069 / 43643	FlyBaseID:	FBgn0039796	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_037144.1	Gene:	Prkg2 / 25523	RGDID:	3401	Length:	762	Species:	Rattus norvegicus

Alignment Length:	308	Identity:	124/308 - (40%)
Similarity:	181/308 - (58%)	Gaps:	11/308 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 KFATNTPSPSTGLDDYEIKATLGSGSFGKVQLVRERESGVYYASKQLSKDQIVKTKQVSHVMSEK 96
            :|::.:|     ..:.||.||||.|.||:|:||:.:...:.:|.|.:.|..||.|||..||.|||
  Rat   443 RFSSTSP-----FQNLEIIATLGVGGFGRVELVKVKNENIAFAMKCIRKKHIVDTKQQEHVYSEK 502

  Fly    97 NVLRSMTFPNTVNLIASYKDFDSLYLVLPLIGGGELFTYHRKVRKFTEKQARFYAAQVFLALEYL 161
            .:|..:..|..|.|..::||...:|::|....||||::..|....|.|..::|..|.|..|.:||
  Rat   503 RILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYL 567

  Fly   162 HHCSLLYRDLKPENIMMDKNGYLKVTDFGFAKKVET--RTMTLCGTPEYLPPEIIQSKPYGTSVD 224
            |...::||||||||:::|.:||||:.|||||||:.:  :|.|.||||||:.||:|.:|.:..|||
  Rat   568 HRLGIIYRDLKPENLILDADGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVD 632

  Fly   225 WWAFGVLVFEFVAGHSPFSAHNRDVMSMYNKICEADYKM--PSYFSGALRHLVDHLLQVDLSKRF 287
            :|:.|:||:|.:.|:.|||  ..|.|..||.|.:...||  |...:.....|:..|.:.:.::|.
  Rat   633 FWSLGILVYELLTGNPPFS--GIDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERL 695

  Fly   288 GNLINGNRDIKEHEWFKDVEWIPLLNQTVNAPYVPNISNPEDISNFDK 335
            |||.||..|||:|.|.....|..|..:::.:|....:|.|.|.|.|||
  Rat   696 GNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLRRELSGPIDHSYFDK 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12069	NP_651819.1	PTZ00263	44..356	CDD:140289	122/296 (41%)
CG12069	NP_651819.1	PKc_like	45..335	CDD:304357	120/293 (41%)
Prkg2	NP_037144.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..138
		Crp	162..>285	CDD:223736
		cGMP-binding, high affinity, cAMP-binding, moderate affinity. /evidence=ECO:0000250\|UniProtKB:Q13237	168..283
		CAP_ED	168..273	CDD:237999
		cGMP-binding, high affinity, cAMP-binding, low affinity. /evidence=ECO:0000250\|UniProtKB:Q13237	286..416
		CAP_ED	286..401	CDD:237999
		PTZ00263	417..752	CDD:140289	124/308 (40%)
		STKc_cGK	459..718	CDD:270724	109/260 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	740..762		3/4 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336592
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840