DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12069 and prkg2

DIOPT Version :9

Sequence 1:	NP_651819.1	Gene:	CG12069 / 43643	FlyBaseID:	FBgn0039796	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	XP_021331649.1	Gene:	prkg2 / 100125912	ZFINID:	ZDB-GENE-060531-80	Length:	769	Species:	Danio rerio

Alignment Length:	340	Identity:	128/340 - (37%)
Similarity:	185/340 - (54%)	Gaps:	29/340 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LDKLREDFNKKFATNTPS---PSTGL--DDYEIK------------------ATLGSGSFGKVQL 63
            :|.|..|..|:.|..:.|   |:|.:  |..|:|                  ||||.|.||:|:|
Zfish   412 VDSLARDDKKRNAKRSGSCTPPNTPVSHDMIELKERESSFASTIPFTCLEAIATLGVGGFGRVEL 476

  Fly    64 VRERESGVYYASKQLSKDQIVKTKQVSHVMSEKNVLRSMTFPNTVNLIASYKDFDSLYLVLPLIG 128
            |:.:...|.:|.|.:.|..||..:|..|:.||:.:|.....|..|.:..:|||...:|::|....
Zfish   477 VKLKNENVTFALKCIKKRHIVDNRQEEHIYSERRILLETNCPFIVKMYRTYKDNKYVYMLLEACL 541

  Fly   129 GGELFTYHRKVRKFTEKQARFYAAQVFLALEYLHHCSLLYRDLKPENIMMDKNGYLKVTDFGFAK 193
            |||:::..|....|.|..|:|....|..|.:|||:..::||||||||:|:|.:||:|:.||||||
Zfish   542 GGEIWSLLRDRGSFEEYTAKFCVGCVTEAFDYLHNNGIIYRDLKPENLMLDTDGYVKLVDFGFAK 606

  Fly   194 KVE--TRTMTLCGTPEYLPPEIIQSKPYGTSVDWWAFGVLVFEFVAGHSPFSAHNRDVMSMYNKI 256
            |::  .||.|.||||||:.||||.:|.:|.|||:|:.|:|:||.:.|..||:  ..|.|.:|..|
Zfish   607 KLKCGQRTWTFCGTPEYVAPEIILNKGHGLSVDFWSLGILIFELLTGSPPFT--GSDQMIIYTFI 669

  Fly   257 CEADYKM--PSYFSGALRHLVDHLLQVDLSKRFGNLINGNRDIKEHEWFKDVEWIPLLNQTVNAP 319
            .:...||  |...:.....|:..|.:.:.|:|.|||.||..|||:|.||....|..|..:.:.:|
Zfish   670 LKGIEKMDFPKKITKRPGDLIRKLCRQNPSERLGNLKNGITDIKKHRWFTGFSWSGLKARNLISP 734

  Fly   320 YVPNISNPEDISNFD 334
            ....:..|.|.|.||
Zfish   735 LKREVKGPTDHSYFD 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12069	NP_651819.1	PTZ00263	44..356	CDD:140289	120/315 (38%)
CG12069	NP_651819.1	PKc_like	45..335	CDD:304357	120/312 (38%)
prkg2	XP_021331649.1	CAP_ED	176..284	CDD:237999
		CAP_ED	293..408	CDD:237999
		STKc_cGK	466..725	CDD:270724	108/260 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575726
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840