Protein Alignment Spn100A and SERPINE1

DIOPT Version :10

• Sequence 1: NP_651818.1
• Gene: Spn100A / 43642
• FlyBaseID: FBgn0039795
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_001373389.1
• Gene: SERPINE1 / 5054
• HGNCID: 8583
• Length: 492
• Species: Homo sapiens
• Alignment Length: 629
• Identity: 114/629 - (18%)
• Similarity: 185/629 - (29%)
• Gaps: 261/629 - (41%)

  Fly     1 MKAVLCAIFVTLLAAIGQGLPTQLEDENHGSFAGQVSQLIALQLLKFNKDIDANQVHSPLGVASI 65
            |...|..:.:.|....|:|.............|......:..|:.:.:|  |.|.|.||.||||:
Human     3 MSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASK--DRNVVFSPYGVASV 65

  Fly    66 LAMLAEASEGDTYSEFEQVFGYPKD----RTKLRDAYKRILGSYQNRDAAVALPSFQTWLYIYRN 126
            ||||...:.|:|..:.:...|:..|    ...||..||.::|
Human    66 LAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMG----------------------- 107

  Fly   127 NSAREEFKDLLEKHYYVDVKDISRQEYDWNEPNTSLQLSEEKDNTDSTEGSTEQSNSKDVIGFET 191
                                       .||           ||...:|:....|.:.|.|.||
Human   108 ---------------------------PWN-----------KDEISTTDAIFVQRDLKLVQGF-- 132

  Fly   192 LKRIKLDDEDIPAIPSDGYGQEIIDKEASKFDRDVDDKQYVEKPVAQAEAELLQKEQKQQATTES 256
                         :|              .|.|                  |.:...||
Human   133 -------------MP--------------HFFR------------------LFRSTVKQ------ 146

  Fly   257 ELESQPEETTTLSVEKQEKPDMAAEENPAEKQQNKRSDQEESQIKNLEENETVQEEEKLAKIMAA 321
                                                                             
Human   147 ----------------------------------------------------------------- 146

  Fly   322 PALTAGEPEKVRLPLQKLENAVKTAAKDGADEIMLALESHLPSVSRVNGARSLFQQDDITSALSA 386
              :...|.|:.|.   .:.:.|||..|.              .:|.:.|..::   |.:|
Human   147 --VDFSEVERARF---IINDWVKTHTKG--------------MISNLLGKGAV---DQLT----- 184

  Fly   387 NSITGRSAGSKSKMLLFNGLYYRGSWANPFYQLRDGSD--EFFFMTNEDAVKAPMMHARGKFQVA 449
                        :::|.|.||:.|.|..||   .|.|.  ..|..::...|..|||....||...
Human   185 ------------RLVLVNALYFNGQWKTPF---PDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYT 234

  Fly   450 DLPQVKAR---VLSLPYETSRYALCIVLPDETE----GLSDVISQLQTSDFLLAKKQFQMKELH- 506
            :.......   :|.|||.....::.|..|.|.|    .|::::|..     |::..:..|..|.
Human   235 EFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQ-----LISHWKGNMTRLPR 294

  Fly   507 -ISMPKFQVEETSRSEAMLKQMGLKKVFSRTEAQLSLLSEDPDVHVDEIVQFVNVRVDEGGSSAN 570
             :.:|||.:|........|:.:|:..:|.:.:|..:.||:...:||.:.:|.|.:.|:|.|:.|:
Human   295 LLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVAS 359

  Fly   571 SLSAATMQARTPSVESTVLPVPEPEPELPGVERFEVNRPFAYFI 614
            |.:|..:.||       :.|           |...::|||.:.:
Human   360 SSTAVIVSAR-------MAP-----------EEIIMDRPFLFVV 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn100A	NP_651818.1	serpin	41..>146	CDD:476815	24/108 (22%)
		serpin	<380..627	CDD:381000	58/246 (24%)
SERPINE1	NP_001373389.1	serpinE1_PAI-1	29..393	CDD:381007	109/603 (18%)