Protein Alignment Spn100A and SERPINC1

DIOPT Version :10

• Sequence 1: NP_651818.1
• Gene: Spn100A / 43642
• FlyBaseID: FBgn0039795
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_001373231.1
• Gene: SERPINC1 / 462
• HGNCID: 775
• Length: 505
• Species: Homo sapiens
• Alignment Length: 384
• Identity: 85/384 - (22%)
• Similarity: 151/384 - (39%)
• Gaps: 116/384 - (30%)

  Fly   301 KNLEENETVQEEEKL---AKIMAAPALTAGEPEKVRLPLQKLENAVKTAAKDGADEIMLALESHL 362
            |:|..|||.|:..:|   ||:.               ||...|||.::.|
Human   182 KSLTFNETYQDISELVYGAKLQ---------------PLDFKENAEQSRA--------------- 216

  Fly   363 PSVSRVNGARSLFQQDDITSALSANSITGRSAGSKSKMLLFNGLYY---RGSWANP--------- 415
                .:|...|...:..||..:.:.:|     ...:.::|.|.:|:   |.:...|
Human   217 ----AINKWVSNKTEGRITDVIPSEAI-----NELTVLVLVNTIYFKVLRMALERPQGLPLALQL 272

  Fly   416 ---FYQLRDGS-------------------------DEFFFMTNEDAVKAPMMHARGKF---QVA 449
               |::.||.|                         .|.|:..:.::..|.||:..|||   :||
Human   273 TPFFFKWRDRSPERANGLPKATQGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVA 337

  Fly   450 DLPQVKARVLSLPYETSRYALCIVLPDETEGLSDVISQLQTSDFLLAKKQFQMKELH-----ISM 509
            :..|    ||.||::.....:.::||...:.|:.|..:| |.:.|    |..:.||.     :.|
Human   338 EGTQ----VLELPFKGDDITMVLILPKPEKSLAKVEKEL-TPEVL----QEWLDELEEMMLVVHM 393

  Fly   510 PKFQVEETSRSEAMLKQMGLKKVFSRTEAQL-SLLSED-PDVHVDEIVQFVNVRVDEGGSSANSL 572
            |:|::|:....:..|:.|||..:||..:::| .:::|. .|::|.:......:.|:|.||.|.:.
Human   394 PRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAAS 458

  Fly   573 SAATMQARTPSVESTVLPVPEPEPELPGVERFEVNRPFAYFIVDCQEQFVLASGKIYTP 631
            :|..:..|:.:               |....|:.||||..||.:.....::..|::..|
Human   459 TAVVIAGRSLN---------------PNRVTFKANRPFLVFIREVPLNTIIFMGRVANP 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn100A	NP_651818.1	serpin	41..>146	CDD:476815
		serpin	<380..627	CDD:381000	66/296 (22%)
SERPINC1	NP_001373231.1	serpinC1_AT3	70..504	CDD:381002	85/384 (22%)