Protein Alignment Spn100A and Serpina1c

DIOPT Version :10

• Sequence 1: NP_651818.1
• Gene: Spn100A / 43642
• FlyBaseID: FBgn0039795
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_033271.1
• Gene: Serpina1c / 20702
• MGIID: 891969
• Length: 413
• Species: Mus musculus
• Alignment Length: 644
• Identity: 116/644 - (18%)
• Similarity: 202/644 - (31%)
• Gaps: 255/644 - (39%)

  Fly     3 AVLCAIFVTLLAAIGQGLPTQLEDE---------NHGSFAGQVSQLIALQLLKFNKDIDANQVHS 58
            |.||.:..:.||...|...|..:|:         |.|.||      |:|.....::...:|...|
Mouse    13 AGLCCLVPSFLAEDVQETDTSQKDQSPASHEIATNLGDFA------ISLYRELVHQSNTSNIFFS 71

  Fly    59 PLGVASILAMLAEASEGDTYSEFEQVFGYPKDRTKLRDAYKRILGSYQNRDAAVALPSFQTWLYI 123
            |:.:|:..|||:..|:|||:::..:...:...:|...|.:|
Mouse    72 PVSIATAFAMLSLGSKGDTHTQILEGLQFNLTQTSEADIHK------------------------ 112

  Fly   124 YRNNSAREEFKDLLEKHYYVDVKDISRQEYDWNEPNTSLQLSEEKDNTDSTEGSTEQSNSKDVIG 188
                    .|:.||:               ..|.|::.|||
Mouse   113 --------SFQHLLQ---------------TLNRPDSELQL------------------------ 130

  Fly   189 FETLKRIKLDDEDIPAIPSDGYGQEIIDKEASKFDRDVDDKQYVEKPVAQAEAELLQKEQKQQAT 253
                              |.|.|..:           .:|.:.|||.:.:|
Mouse   131 ------------------STGNGLFV-----------NNDLKLVEKFLEEA-------------- 152

  Fly   254 TESELESQPEETTTLSVEKQEKPDMAAEENPAEKQQNKRSDQEESQIKNLEENETVQEEEKLAKI 318
                                                 |...|.|....|..|:|.       ||.
Mouse   153 -------------------------------------KNHYQAEVFSVNFAESEE-------AKK 173

  Fly   319 MAAPALTAGEPEKVRLPLQKLENAVKTAAKDGADEIMLALESHLPSVSRVNGARSLFQQDDITSA 383
            :....:..|...|:...::||:                                    ||.:
Mouse   174 VINDFVEKGTQGKIAEAVKKLD------------------------------------QDTV--- 199

  Fly   384 LSANSITGRSAGSKSKMLLFNGLYYRGSWANPFYQLRDGSDEFFFMTNED-AVKAPMMHARGKFQ 447
                            ..|.|.:.::|.|..||..  :.::|..|..:|. .||.|||...|...
Mouse   200 ----------------FALANYILFKGKWKKPFDP--ENTEEAEFHVDESTTVKVPMMTLSGMLD 246

  Fly   448 VADLPQVKARVLSLPYETSRYALCIVLPDE--TEGLSDVISQLQTSDFLLAKKQFQMKELHISMP 510
            |.....:.:.||.:.|..:..|: .:|||:  .:.|...:|:...|.||| |:..::.::|  .|
Mouse   247 VHHCSTLSSWVLLMDYAGNATAV-FLLPDDGKMQHLEQTLSKELISKFLL-KRPRRLAQIH--FP 307

  Fly   511 KFQVEETSRSEAMLKQMGLKKVFSRTEAQLSLLSEDPDVHVDEIVQFVNVRVDEGGSSANSLSAA 575
            :..:......:.::..:|:.::|:.......:..|:..:.:.:.|....:.:||.|:.|   :||
Mouse   308 RLSISGEYNLKTLMSPLGITRIFNNGADLSGITEENAPLKLSQAVHKAVLTMDETGTEA---AAA 369

  Fly   576 TMQARTPSVESTVLPVPEPEPELPGVERFEVNRPFAYFIVDCQEQFVLASGKIYTPEFK 634
            |:          :|.||.   .:|.:.||:  .||.:.|.:...|..|..||:..|..|
Mouse   370 TV----------LLAVPY---SMPPIVRFD--HPFLFIIFEEHTQSPLFVGKVVDPTHK 413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn100A	NP_651818.1	serpin	41..>146	CDD:476815	18/104 (17%)
		serpin	<380..627	CDD:381000	54/249 (22%)
Serpina1c	NP_033271.1	serpinA1_A1AT	44..412	CDD:381012	107/610 (18%)