Protein Alignment Spn100A and Serpine1

DIOPT Version :10

• Sequence 1: NP_651818.1
• Gene: Spn100A / 43642
• FlyBaseID: FBgn0039795
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_032897.2
• Gene: Serpine1 / 18787
• MGIID: 97608
• Length: 402
• Species: Mus musculus
• Alignment Length: 652
• Identity: 100/652 - (15%)
• Similarity: 189/652 - (28%)
• Gaps: 273/652 - (41%)

  Fly     1 MKAVLCAIFVTLLAAIGQGLPTQLEDENHGSFAGQVSQLIALQLLKFNKDIDANQVHSPLGVASI 65
            |.:.|..:.:.|:...|:|....|.:.:....|......:..|:::.:|  |.|.|.||.||:|:
Mouse     3 MSSALACLILGLVLVSGKGFTLPLRESHTAHQATDFGVKVFQQVVQASK--DRNVVFSPYGVSSV 65

  Fly    66 LAMLAEASEGDTYSEFEQVFGYPKDRT----KLRDAYKRILGSYQNRDAAVALPSFQTWLYIYRN 126
            ||||...:.|.|..:.:...|:..:..    .||...|.::|.:...:.:.|     ..:::.|:
Mouse    66 LAMLQMTTAGKTRRQIQDAMGFKVNEKGTAHALRQLSKELMGPWNKNEISTA-----DAIFVQRD 125

  Fly   127 NSAREEFKDLLEKHYY---------VDVKDISRQEY---DWNEPNTSLQLSEEKDNTDSTEGSTE 179
            ....:.|.    .|::         ||..::.|..:   ||.|.:|...:|
Mouse   126 LELVQGFM----PHFFKLFQTMVKQVDFSEVERARFIINDWVERHTKGMIS-------------- 172

  Fly   180 QSNSKDVIGFETLKRIKLDDEDIPAIPSDGYGQEIIDKEASKFDRDVDDKQYVEKPVAQAEAELL 244
                                                                          :||
Mouse   173 --------------------------------------------------------------DLL 175

  Fly   245 QKEQKQQATTESELESQPEETTTLSVEKQEKPDMAAEENPAEKQQNKRSDQEESQIKNLEENETV 309
                                                                             
Mouse   176 ----------------------------------------------------------------- 175

  Fly   310 QEEEKLAKIMAAPALTAGEPEKVRLPLQKLENAVKTAAKDGADEIMLALESHLPSVSRVNGARSL 374
                                                 ||...||:
Mouse   176 -------------------------------------AKGAVDEL-------------------- 183

  Fly   375 FQQDDITSALSANSITGRSAGSKSKMLLFNGLYYRGSWANPFYQLRDGSDEFFFMTNEDAVKAPM 439
                                   ::::|.|.||:.|.|..||.: .......|..::...|..||
Mouse   184 -----------------------TRLVLVNALYFSGQWKTPFLE-ASTHQRLFHKSDGSTVSVPM 224

  Fly   440 MHARGKFQVADLPQ---VKARVLSLPYETSRYALCIVLPDETEGLSDVISQLQTSDFLLAKKQFQ 501
            |....||...:...   ::..|:.|||:....::.|..|.|.:.....::.:..:: |:.:.:..
Mouse   225 MAQSNKFNYTEFTTPDGLEYDVVELPYQGDTLSMFIAAPFEKDVHLSALTNILDAE-LIRQWKGN 288

  Fly   502 MKELH--ISMPKFQVEETSRSEAMLKQMGLKKVFSRTEAQLSLLSEDPDVHVDEIVQFVNVRVDE 564
            |..|.  :.:|||.:|........|:::|:..:||.|.|..:.||:...:.|.:.:|.|.:.|:|
Mouse   289 MTRLPRLLILPKFSLETEVDLRGPLEKLGMPDMFSATLADFTSLSDQEQLSVAQALQKVRIEVNE 353

  Fly   565 GGSSANSLSAATMQARTPSVESTVLPVPEPEPELPGVERFEVNRPFAYFIVDCQEQFVLASGKIY 629
            .|:.|:|.:|..:.||....|..                  ::|.|.:.:.....:.:|..|::.
Mouse   354 SGTVASSSTAFVISARMAPTEMV------------------IDRSFLFVVRHNPTETILFMGQVM 400

  Fly   630 TP 631
            .|
Mouse   401 EP 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn100A	NP_651818.1	serpin	41..>146	CDD:476815	27/117 (23%)
		serpin	<380..627	CDD:381000	52/251 (21%)
Serpine1	NP_032897.2	serpin	29..402	CDD:476815	93/624 (15%)