Protein Alignment Spn100A and Serpind1

DIOPT Version :10

• Sequence 1: NP_651818.1
• Gene: Spn100A / 43642
• FlyBaseID: FBgn0039795
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_032249.3
• Gene: Serpind1 / 15160
• MGIID: 96051
• Length: 478
• Species: Mus musculus
• Alignment Length: 534
• Identity: 110/534 - (20%)
• Similarity: 198/534 - (37%)
• Gaps: 126/534 - (23%)

  Fly   146 KDISRQEYDWNEPNTSLQLSEEKDNTDSTEGSTEQSNSKDVIGFETLKRIKLDDEDIPAI----P 206
            |.::.|..:.|...:.|..:..|:||.:.:...|....:|.:..|  |.:..||:.|..|    |
Mouse    20 KGLAEQLTNENLTTSFLPANFHKENTVTNDWIPEGEEDEDYLDLE--KLLGEDDDYIYIIDAVSP 82

  Fly   207 SDGYGQEIIDKEASKFDRDVDDKQYVEK-PVAQAE-AELLQKEQKQQATTESELESQPEETTT-- 267
            :|.      :..|....:....|..::: .:..|: |..|.:..|.||||...|...|...:|
Mouse    83 TDS------ESSAGNILQLFQGKSRIQRLNILNAKFAFNLYRVLKDQATTSDNLFIAPVGISTAM 141

  Fly   268 ------LSVEKQEK-------PDMAAEENPAEKQQNKRSDQEESQIKNL---------------- 303
                  |..|..|:       .|..          |..|..|.:.|.||
Mouse   142 GMISLGLRGETHEEVHSVLHFRDFV----------NASSKYEVTTIHNLFRKLTHRLFRRNFGYT 196

  Fly   304 ---------EENETVQEEEKLA--KIMAAPALTAGEPEKVRLPLQKLENAVKTAAKDGADEIMLA 357
                     ::...::|:.|.|  :...|.|..|..|:...  :.|..|.:....|....|   |
Mouse   197 LRSVNGLYIQKQFPIREDFKAAMREFYFAEAQEANFPDPAF--ISKANNHILKLTKGLIKE---A 256

  Fly   358 LESHLPSVSRVNGARSLFQQDDITSALSANSITGRSAGSKSKMLLFNGLYYRGSWANPFYQLRDG 422
            ||:..|:                                 ::||:.|.:|::|:|.|.| .:...
Mouse   257 LENIDPA---------------------------------TQMLILNCIYFKGTWVNKF-PVEMT 287

  Fly   423 SDEFFFMTNEDAVKAPMMHARGKFQVADLPQVKARVLSLPYETSRYALCIVLPDETEGLSDVISQ 487
            .:..|.:...:.||..||..:|.|..|:..::...:|.|.| ....::.||:|.:..|:..:.:|
Mouse   288 HNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEY-VGGISMLIVVPRKLSGMKTLEAQ 351

  Fly   488 LQTSDFLLAKKQFQMKELHISMPKFQVEETSRSEAMLKQMGLKKVFSRTEAQLSLLSEDPDVHVD 552
            |........:|....:...:.:|||::|:......:||.||:.|:|:: ...:|.:| |..:.:|
Mouse   352 LTPQVVERWQKSMTNRTREVLLPKFKLEKNYNLVEVLKSMGITKLFNK-NGNMSGIS-DQRIAID 414

  Fly   553 EIVQFVNVRVDEGGSSANSLSAATMQARTPSVESTVLPVPEPEPELPGVERFEVNRPFAYFIVDC 617
            .......:.|:|.|:.|.:::.......:..|                  ||.|:|||.:.:.:.
Mouse   415 LFKHQSTITVNEEGTQAAAVTTVGFMPLSTQV------------------RFTVDRPFLFLVYEH 461

  Fly   618 QEQFVLASGKIYTP 631
            :...:|..||:..|
Mouse   462 RTSCLLFMGKVTNP 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn100A	NP_651818.1	serpin	41..>146	CDD:476815	110/534 (21%)
		serpin	<380..627	CDD:381000	52/246 (21%)
Serpind1	NP_032249.3	serpinD1_HCF2	32..478	CDD:381004	107/522 (20%)
		2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)	54..78		6/25 (24%)
		Glycosaminoglycan-binding site. /evidence=ECO:0000250	171..191		4/19 (21%)