Protein Alignment Spn100A and SERPINA12

DIOPT Version :10

• Sequence 1: NP_651818.1
• Gene: Spn100A / 43642
• FlyBaseID: FBgn0039795
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_776249.1
• Gene: SERPINA12 / 145264
• HGNCID: 18359
• Length: 414
• Species: Homo sapiens
• Alignment Length: 646
• Identity: 117/646 - (18%)
• Similarity: 198/646 - (30%)
• Gaps: 263/646 - (40%)

  Fly     7 AIFVTLLAAIGQGLPTQLEDENHGSFA---GQVSQLIALQLLKFNKDI-------------DANQ 55
            |||:.:|..:...|.......|:.:.:   |...::.|.:|.:.|.|:             ..|.
Human     8 AIFLAVLLTVKGLLKPSFSPRNYKALSEVQGWKQRMAAKELARQNMDLGFKLLKKLAFYNPGRNI 72

  Fly    56 VHSPLGVASILAMLAEASEGDTYSEFEQVFGYPKDRTKLRDAYKRILGSYQNRDAAVALPSFQTW 120
            ..|||.:::..:||...::..|..|.:|.|.:.|                        :|.
Human    73 FLSPLSISTAFSMLCLGAQDSTLDEIKQGFNFRK------------------------MPE---- 109

  Fly   121 LYIYRNNSAREEFKDLLEKHYYVDVKDISRQEYDWNEPNTSLQLSEEKDNTDSTEGSTEQSNSKD 185
                         |||.|..:|: :.:::::..|       |:||
Human   110 -------------KDLHEGFHYI-IHELTQKTQD-------LKLS-------------------- 133

  Fly   186 VIGFETLKRIKLDDEDIPAIPSDGYGQEIIDKEASKFDRDVDDKQYVEKPVAQAEAELLQKEQKQ 250
             || .||                     .||                            |:.|.|
Human   134 -IG-NTL---------------------FID----------------------------QRLQPQ 147

  Fly   251 QATTESELESQPEETTTLSVEKQEKPDMAAEENPAEKQQNK-RSDQEESQIKNLEENETVQEEEK 314
            :...|........||...:.:..|.         |:||.|. .|.:...:|.||.||.
Human   148 RKFLEDAKNFYSAETILTNFQNLEM---------AQKQINDFISQKTHGKINNLIENI------- 196

  Fly   315 LAKIMAAPALTAGEPEKVRLPLQKLENAVKTAAKDGADEIMLALESHLPSVSRVNGARSLFQQDD 379
                         :|..|
Human   197 -------------DPGTV----------------------------------------------- 201

  Fly   380 ITSALSANSITGRSAGSKSKMLLFNGLYYRGSWANPFYQLRDGS---DEFFFMTNEDAVKAPMMH 441
                                |||.|.:::|..|.:.|    |.:   :|.||:....:||.|||.
Human   202 --------------------MLLANYIFFRARWKHEF----DPNVTKEEDFFLEKNSSVKVPMMF 242

  Fly   442 ARGKFQVADLPQVKARVLSLPYETSRYALCIVLPDETEGLSDVISQLQTSDFLLAKKQFQMKELH 506
            ..|.:||....::...:|.:||:.:..|: .:||||.: |..:...||...|...|.....:.:.
Human   243 RSGIYQVGYDDKLSCTILEIPYQKNITAI-FILPDEGK-LKHLEKGLQVDTFSRWKTLLSRRVVD 305

  Fly   507 ISMPKFQVEETSRSEAMLKQMGLKKVFSRTEAQLSLLSEDPDVHVDEIVQFVNVRVDEGGS-SAN 570
            :|:|:..:..|...:..|..:|:.|:|.. ...|:.::....:.|.|.|....:::||.|: .|.
Human   306 VSVPRLHMTGTFDLKKTLSYIGVSKIFEE-HGDLTKIAPHRSLKVGEAVHKAELKMDERGTEGAA 369

  Fly   571 SLSAATMQARTPSVESTVLPVPEPEPELPGVERFEVNRPFAYFIVDCQEQFVLASGKIYTP 631
            ...|.|:...||.|                   .::::|:...|...:...||..|||..|
Human   370 GTGAQTLPMETPLV-------------------VKIDKPYLLLIYSEKIPSVLFLGKIVNP 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn100A	NP_651818.1	serpin	41..>146	CDD:476815	21/117 (18%)
		serpin	<380..627	CDD:381000	56/250 (22%)
SERPINA12	NP_776249.1	serpinA12_vaspin	40..411	CDD:381026	109/612 (18%)
		Reactive center loop. /evidence=ECO:0000269|PubMed:26529565, ECO:0000305|PubMed:23370777, ECO:0000305|PubMed:26199422	364..382		5/17 (29%)