Protein Alignment Spn100A and SERPINA3

DIOPT Version :10

• Sequence 1: NP_651818.1
• Gene: Spn100A / 43642
• FlyBaseID: FBgn0039795
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_001076.2
• Gene: SERPINA3 / 12
• HGNCID: 16
• Length: 423
• Species: Homo sapiens
• Alignment Length: 328
• Identity: 67/328 - (20%)
• Similarity: 137/328 - (41%)
• Gaps: 55/328 - (16%)

  Fly   337 QKLENAVKTAAKDGADEIMLA-------------LESHLPSVSRVNGARSL---FQQDDITSALS 385
            |..::.::| ....:||:.|:             |:.......|:.|:.:.   ||.......|.
Human   117 QSFQHLLRT-LNQSSDELQLSMGNAMFVKEQLSLLDRFTEDAKRLYGSEAFATDFQDSAAAKKLI 180

  Fly   386 ANSITGRSAG----------SKSKMLLFNGLYYRGSWANPFYQLRDGSDEFFFMTNEDAVKAPMM 440
            .:.:...:.|          |::.|:|.|.::::..|..|| ..:|.....|:::.:..|..|||
Human   181 NDYVKNGTRGKITDLIKDLDSQTMMVLVNYIFFKAKWEMPF-DPQDTHQSRFYLSKKKWVMVPMM 244

  Fly   441 HARGKFQVADLP-----QVKARVLSLPYETSRYALCIVLPDETEGLSDVISQLQTSDFLLAKKQF 500
                ......:|     ::...|:.|.|..:..|| .:|||: :.:.:|.:.|........:...
Human   245 ----SLHHLTIPYFRDEELSCTVVELKYTGNASAL-FILPDQ-DKMEEVEAMLLPETLKRWRDSL 303

  Fly   501 QMKEL-HISMPKFQVEETSRSEAMLKQMGLKKVFSRTEAQLSLLSEDPDVHVDEIVQFVNVRVDE 564
            :.:|: .:.:|||.:........:|.|:|:::.|: ::|.||.::...::.|.::|....:.|.|
Human   304 EFREIGELYLPKFSISRDYNLNDILLQLGIEEAFT-SKADLSGITGARNLAVSQVVHKAVLDVFE 367

  Fly   565 GGSSANSLSAATMQARTPSVESTVLPVPEPEPELPGVERFEVNRPFAYFIVDCQEQFVLASGKIY 629
            .|:.|::.:|..:...:..||:..            :.||  ||||...||....|.:....|:.
Human   368 EGTEASAATAVKITLLSALVETRT------------IVRF--NRPFLMIIVPTDTQNIFFMSKVT 418

  Fly   630 TPE 632
            .|:
Human   419 NPK 421

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn100A	NP_651818.1	serpin	41..>146	CDD:476815
		serpin	<380..627	CDD:381000	55/262 (21%)
SERPINA3	NP_001076.2	serpinA3_A1AC	40..421	CDD:381019	66/326 (20%)
		RCL	369..394		5/36 (14%)
		O-glycosylated at one site	381..389		1/7 (14%)