DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaPV and P4HA2

DIOPT Version :9

Sequence 1:	NP_733395.1	Gene:	PH4alphaPV / 43640	FlyBaseID:	FBgn0051015	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001136071.1	Gene:	P4HA2 / 8974	HGNCID:	8547	Length:	535	Species:	Homo sapiens

Alignment Length:	511	Identity:	169/511 - (33%)
Similarity:	277/511 - (54%)	Gaps:	30/511 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 TSVAGMVKLLDLEAQLIDNLEDYAVELEKKLQTVRRSITSLRLENDKARSSTEEYLSNPLNSFSL 98
            ||:..|..|:..|.:|:.:|::|.:..|.||..::.....:.....|:.:..|.||::|:|::.|
Human    25 TSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWANKMEALTSKSAADAEGYLAHPVNAYKL 89

  Fly    99 IRRMNRDWIIWQ--LYMDDPVGISQVERIQELREHMPTHTDVEEAVTALDRIQSTYGLKVPEISH 161
            ::|:|.||...:  :..|...|.  :..:...|:..||..|...|..||.|:|.||.|....||.
Human    90 VKRLNTDWPALEDLVLQDSAAGF--IANLSVQRQFFPTDEDEIGAAKALMRLQDTYRLDPGTISR 152

  Fly   162 GFLNGKQYNVSLTVLDTYAMGQILFDQKNYLAAASWIYQSVVLMEAFSMAAPLEISKNEVRMVYA 226
            |.|.|.:|...|:|.|.:.||:..:::.:|.....|:.|.:..::|...|.   .:|::|....:
Human   153 GELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQLDAGEEAT---TTKSQVLDYLS 214

  Fly   227 ETLLKLNQHADALKVVNIALTDNP-HD--------IKLLLKKSEIETMI-RTGTNNAPPVKVQAT 281
            ..:.:|.....||::....|:.:| |:        .:.||::...:|:. :|....|.|..:...
Human   215 YAVFQLGDLHRALELTRRLLSLDPSHERAGGNLRYFEQLLEEEREKTLTNQTEAELATPEGIYER 279

  Fly   282 GVP-----TAYQIGCRGQ---FPPSADSKLYCLYNR-TTSPFLILAPLKMELVGLDPYMVLYHDV 337
            .|.     ..|:..|||:   ..|....:|:|.|:. ..:|.|::||.|.|.....|::|.|:||
Human   280 PVDYLPERDVYESLCRGEGVKLTPRRQKRLFCRYHHGNRAPQLLIAPFKEEDEWDSPHIVRYYDV 344

  Fly   338 LSPKEIKELQGMATPGLKRATVYQASSGRNEVVKTRTSKVAWFPDGYNPLTVRLNARISDMTGFN 402
            :|.:||:.::.:|.|.|.||||....:|...|...|.||.:|..:..:|:..|:|.|:..:||..
Human   345 MSDEEIERIKEIAKPKLARATVRDPKTGVLTVASYRVSKSSWLEEDDDPVVARVNRRMQHITGLT 409

  Fly   403 LYGSEMLQLMNYGLGGHYDQHYDFFNKTNSNMTAM---SGDRIATVLFYLTDVEQGGATVFPNIR 464
            :..:|:||:.|||:||.|:.|:| |::.:...|..   :|:|:||.|.|::|||.|||||||::.
Human   410 VKTAELLQVANYGVGGQYEPHFD-FSRNDERDTFKHLGTGNRVATFLNYMSDVEAGGATVFPDLG 473

  Fly   465 KAVFPQRGSVVMWYNLKDNGQIDTQTLHAACPVIVGSKWVCNKWIREREQIFSRPC 520
            .|::|::|:.|.||||..:|:.|.:|.||||||:||.|||.|||..||.|.|.|||
Human   474 AAIWPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPC 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaPV	NP_733395.1	P4Ha_N	35..164	CDD:285528	38/130 (29%)
		TPR_11	179..250	CDD:290150	13/70 (19%)
		TPR repeat	179..213	CDD:276809	7/33 (21%)
		TPR repeat	218..248	CDD:276809	6/29 (21%)
		P4Hc	339..510	CDD:214780	76/173 (44%)
P4HA2	NP_001136071.1	P4Ha_N	26..155	CDD:311993	38/130 (29%)
		TPR	207..240		6/32 (19%)
		P4Hc	346..519	CDD:214780	76/173 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100878
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920