DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaPV and P4htm

DIOPT Version :9

Sequence 1:	NP_733395.1	Gene:	PH4alphaPV / 43640	FlyBaseID:	FBgn0051015	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_083220.3	Gene:	P4htm / 74443	MGIID:	1921693	Length:	503	Species:	Mus musculus

Alignment Length:	499	Identity:	110/499 - (22%)
Similarity:	174/499 - (34%)	Gaps:	165/499 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 YLSNPLNSFSLIRRMNRDWIIWQLYMDDPVGISQVERIQELREHMPTHTDVEEAVTALDRIQSTY 152
            ||.|.|.....:...|.|      ...||.        .:.||..|........:|.|:.|:..|
Mouse    72 YLGNVLALLLFVHYSNGD------ESTDPG--------PQRREQSPQPVPTLGPLTRLEGIKVGY 122

  Fly   153 GLKVPEISHGFLNGKQYNVSLTVLDTYAMGQILFDQKNYLAAASWIYQSVVLMEAFSMAAPLEIS 217
            ..||..::     |:.:     .:.|.::..:||:...:|:               .....|.|.
Mouse   123 ERKVQVVA-----GRDH-----FIRTLSLKPLLFEIPGFLS---------------DEECRLIIH 162

  Fly   218 KNEVRMVYAETLLKLNQHADALKVVNIA------LTDNPHDIKLLLKKSEIETMIRTGTNNAPPV 276
            ..:::.:....:|...::.:|:..:.::      |.|..||.:|.|::...:|.:..|.
Mouse   163 LAQMKGLQRSQILPTEEYEEAMSAMQVSQLDLFQLLDQNHDGRLQLREVLAQTRLGNGR------ 221

  Fly   277 KVQATGVPTAYQIGCRGQFPPSADSKLYCLYNRTTSPFLILAPLKMELVGLDPYMVLYHDVLSPK 341
                             ...|....::|             :.:|.:..|        ..|||
Mouse   222 -----------------WMTPENIQEMY-------------SAIKADPDG--------DGVLS-- 246

  Fly   342 EIKELQGMATPGLKRATVYQAS--SGRNEVVKTRTSKVAWFPDG---------YNPLTVRLNARI 395
                ||..:...|:....|..|  :..||:|  |.|...|...|         .....:||....
Mouse   247 ----LQEFSNMDLRDFHKYMRSHKAESNELV--RNSHHTWLHQGEGAHHVMRAIRQRVLRLTRLS 305

  Fly   396 SDMTGFNLYGSEMLQLMNYGLGGHYDQHYD---FFNKT---------NSNMTAMSGDRIATVLFY 448
            .::..|    ||.||::.||.||||..|.|   .:.:|         |.::...:..|..|||||
Mouse   306 PEIVEF----SEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRYMTVLFY 366

  Fly   449 LTDVEQGGATVFP-----------------------------NIRKAVFPQRGSVVMWYNLKDNG 484
            |.:|..||.||||                             |:|  |.||:|:.|.|||...:|
Mouse   367 LNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLR--VKPQQGTAVFWYNYLPDG 429

  Fly   485 Q-----IDTQTLHAACPVIVGSKWVCNKWI-----REREQIFSR 518
            |     :|..:||..|.|..|:||:.|.||     |.|:.:|.:
Mouse   430 QGWVGEVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQ 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaPV	NP_733395.1	P4Ha_N	35..164	CDD:285528	17/75 (23%)
		TPR_11	179..250	CDD:290150	9/76 (12%)
		TPR repeat	179..213	CDD:276809	3/33 (9%)
		TPR repeat	218..248	CDD:276809	3/35 (9%)
		P4Hc	339..510	CDD:214780	67/232 (29%)
P4htm	NP_083220.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..110		5/27 (19%)
		EF-hand_7	193..253	CDD:290234	17/109 (16%)
		EFh	195..253	CDD:298682	17/107 (16%)
		P4Hc	247..459	CDD:214780	64/219 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839363
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740