DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaPV and P4ha1

DIOPT Version :9

Sequence 1:	NP_733395.1	Gene:	PH4alphaPV / 43640	FlyBaseID:	FBgn0051015	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_742059.2	Gene:	P4ha1 / 64475	RGDID:	621000	Length:	534	Species:	Rattus norvegicus

Alignment Length:	539	Identity:	173/539 - (32%)
Similarity:	278/539 - (51%)	Gaps:	43/539 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LTYQVLL--LLLRQAKGEESHCTSVAGMVKLLDLEAQLIDNLEDYAVELEKKLQTVRRSITSLRL 76
            :.:.||:  :||.|........||:..|..|:..|..|:.:|:||....|.||:.:::....|..
  Rat     1 MIWGVLMMGILLPQCSAHPGFFTSIGQMTDLIHNEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDR 65

  Fly    77 ENDKARSSTEEYLSNPLNSFSLIRRMNRDWI-IWQLYMDDPVGISQVERIQELREHMPTHTDVEE 140
            ....|....|.::.:|:|:|.|::|:|.:|. :..|.:.| :....:..:...|::.|...|...
  Rat    66 LTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLILKD-MSDGFISNLTIQRQYFPNDEDQVG 129

  Fly   141 AVTALDRIQSTYGLKVPEISHGFLNGKQYNVSLTVLDTYAMGQILFDQKNYLAAASWIYQSVVLM 205
            |..||.|:|.||.|....||.|.|.|.::...||..|.:.:|::.:.:.:|.....|:.|:::.:
  Rat   130 AAKALFRLQDTYNLDTNTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADYYHTELWMEQALMQL 194

  Fly   206 EAFSMAAPLEISKNEVRMVYAETLLKLNQHADALKVVNIALT------DNPHD--------IKLL 256
            |...|:...::|..:. :.||     :.|..|..|.  :.||      |..|.        .:.:
  Rat   195 EEGEMSTVDKVSVLDY-LSYA-----VYQQGDLDKA--LLLTKKLLELDPEHQRANGNLVYFEYI 251

  Fly   257 LKKSEIETMIRTGTNNAPPVKVQATGVPT-------AYQIGCRGQ---FPPSADSKLYCLY---N 308
            :.|.:......:|..:......:..|:..       .|::.|||:   ..|....:|:|.|   |
  Rat   252 MSKEKDANKSASGDQSDQKTTPKKKGIAVDYLPERQKYEMLCRGEGIKMTPRRQKRLFCRYHDGN 316

  Fly   309 RTTSPFLILAPLKMELVGLDPYMVLYHDVLSPKEIKELQGMATPGLKRATVYQASSGRNEVVKTR 373
            |  :|..||||.|.|.....|.::.:||::|..||:.::.:|.|.|.||||:...:|:....:.|
  Rat   317 R--NPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLSRATVHDPETGKLTTAQYR 379

  Fly   374 TSKVAWFPDGYNPLTVRLNARISDMTGFNLYGSEMLQLMNYGLGGHYDQHYDFFNKTNSN--MTA 436
            .||.||.....:|:..|:|.||.|:||.::..:|.||:.|||:||.|:.|:||..|...:  ...
  Rat   380 VSKSAWLSGYEDPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDAFREL 444

  Fly   437 MSGDRIATVLFYLTDVEQGGATVFPNIRKAVFPQRGSVVMWYNLKDNGQIDTQTLHAACPVIVGS 501
            .:|:||||.|||::||..|||||||.:..:|:|::|:.|.||||..:|:.|..|.||||||:||:
  Rat   445 GTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVLVGN 509

  Fly   502 KWVCNKWIREREQIFSRPC 520
            |||.|||:.||.|.|.|||
  Rat   510 KWVSNKWLHERGQEFRRPC 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaPV	NP_733395.1	P4Ha_N	35..164	CDD:285528	37/129 (29%)
		TPR_11	179..250	CDD:290150	15/76 (20%)
		TPR repeat	179..213	CDD:276809	6/33 (18%)
		TPR repeat	218..248	CDD:276809	7/35 (20%)
		P4Hc	339..510	CDD:214780	79/172 (46%)
P4ha1	NP_742059.2	P4Ha_N	25..112	CDD:400573	22/87 (25%)
		TPR	205..238		9/40 (23%)
		P4Hc	345..518	CDD:214780	79/172 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100878
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.820