DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaPV and p4ha1a

DIOPT Version :9

Sequence 1:	NP_733395.1	Gene:	PH4alphaPV / 43640	FlyBaseID:	FBgn0051015	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	XP_009304776.1	Gene:	p4ha1a / 562774	ZFINID:	ZDB-GENE-040724-91	Length:	541	Species:	Danio rerio

Alignment Length:	550	Identity:	180/550 - (32%)
Similarity:	276/550 - (50%)	Gaps:	51/550 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLPVRVLLTYQVLLLLLRQAKGEESHCTSVAGMVKLLDLEAQLIDNLEDYAVELEKKLQTVRRSI 71
            ::.||.:..: :|:.||:.:.......||:..|..||..|..|:.:|:||....|.||:.|::..
Zfish     1 MMGVRSVCCF-LLISLLKSSSAHSDFFTSIGHMTDLLFTEKDLVTSLKDYIKAEESKLEQVKQWA 64

  Fly    72 TSLRLENDKARSSTEEYLSNPLNSFSLIRRMNRDW-IIWQLYMDDPVGISQVERIQELREHMPTH 135
            ..|......|....|.:|.:|:|:|.|::|:|.:| .:..|.:.| :....:..:...|::.|..
Zfish    65 EKLDALTATAVQDPEGFLGHPVNAFKLMKRLNTEWGEVEDLVLKD-MSDGFISNLTIQRQYFPND 128

  Fly   136 TDVEEAVTALDRIQSTYGLKVPEISHGFL----NGKQYNVSLTVLDTYAMGQILFDQKNYLAAAS 196
            .|...|..||.|:|.||.|....||.|.|    .|..|..:|||.|.:.:|:|.:...:|.....
Zfish   129 EDQNGAAKALLRLQDTYKLDTQTISSGDLPGVNTGLPYKSTLTVEDCFELGKIAYSDADYYHTEL 193

  Fly   197 WIYQSVVLMEAFSMAAPLEISKNEVRMVYAETLLKLNQHAD-----ALKVVNIALTDNPHDIKLL 256
            |:.|::..::        |..::.|.:..|...|..:.:..     ||:.....||..|...:.|
Zfish   194 WMAQALKQLD--------EGEESSVEIATALDYLSYSVYQQGELERALEYTKRLLTVEPEHQRAL 250

  Fly   257 ------------LKKSEIETMIRTGTNNAPPVKVQATG------VP--TAYQIGCRGQ---FPPS 298
                        .||:|.|...:..:.     |.|.|.      :|  ..|:..|||:   ..|.
Zfish   251 GNLKYFDYQLAKQKKAEKEQSTKEESK-----KEQETSDGKKEYLPEKRKYEKLCRGEGLKMTPR 310

  Fly   299 ADSKLYCLY-NRTTSPFLILAPLKMELVGLDPYMVLYHDVLSPKEIKELQGMATPGLKRATVYQA 362
            ....|:|.| |....||..:.|:|.|.....|.::.||::::.:||::::.::.|.|:|||:...
Zfish   311 RQKHLFCRYFNGNRHPFYTIGPVKQEDEWDRPRIIRYHEIITEQEIEKIKELSKPRLRRATISNP 375

  Fly   363 SSGRNEVVKTRTSKVAWFPDGYNPLTVRLNARISDMTGFNLYGSEMLQLMNYGLGGHYDQHYDFF 427
            .:|..|....|.||.||.....:|:..|:|.||.|:||.|:..:|.||:.|||:||.|:.|:||.
Zfish   376 ITGVLETAHYRISKSAWLAAYEHPVVDRINQRIEDITGLNVKTAEELQVANYGVGGQYEPHFDFG 440

  Fly   428 NKTNSN--MTAMSGDRIATVLFYLTDVEQGGATVFPNIRKAVFPQRGSVVMWYNLKDNGQIDTQT 490
            .|...:  ....:|:||||.|||::||..|||||||.:..||.|.:|:.|.||||..:|:.|..|
Zfish   441 RKDEPDAFKELGTGNRIATWLFYMSDVAAGGATVFPEVGAAVKPLKGTAVFWYNLFPSGEGDYST 505

  Fly   491 LHAACPVIVGSKWVCNKWIREREQIFSRPC 520
            .||||||:||:|||.||||.||.|.|.|||
Zfish   506 RHAACPVLVGNKWVSNKWIHERGQEFRRPC 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaPV	NP_733395.1	P4Ha_N	35..164	CDD:285528	40/129 (31%)
		TPR_11	179..250	CDD:290150	13/75 (17%)
		TPR repeat	179..213	CDD:276809	5/33 (15%)
		TPR repeat	218..248	CDD:276809	6/34 (18%)
		P4Hc	339..510	CDD:214780	79/172 (46%)
p4ha1a	XP_009304776.1	P4Ha_N	28..157	CDD:285528	40/129 (31%)
		TPR repeat	172..207	CDD:276809	8/42 (19%)
		TPR repeat	212..242	CDD:276809	5/29 (17%)
		Fis1	218..262	CDD:304536	7/43 (16%)
		P4Hc	352..525	CDD:214780	79/172 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583423
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100878
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.750