DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaPV and zgc:152670

DIOPT Version :9

Sequence 1:	NP_733395.1	Gene:	PH4alphaPV / 43640	FlyBaseID:	FBgn0051015	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001070123.2	Gene:	zgc:152670 / 557059	ZFINID:	ZDB-GENE-060929-954	Length:	490	Species:	Danio rerio

Alignment Length:	522	Identity:	152/522 - (29%)
Similarity:	250/522 - (47%)	Gaps:	87/522 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 EESHCTSVAGMVKLLDLEAQLIDNLEDYAVELEKKLQTVRRSITSLRLENDKARSSTEEYLSNPL 93
            |:...:||..:.:|.:.|..|:|....|....|:.|:.::..:..|:|.:.....|.||.:.:|:
Zfish    20 EQEFFSSVDQVSQLFNEEENLLDTFSLYIDAEEENLKKMKSLLLLLQLGSFSNPQSPEETMRDPV 84

  Fly    94 NSFSLIRRMNRDWIIWQLYMDDPVGISQVERIQELREH--MPTHTDVEEAVTALDRIQSTYGLKV 156
            .:|.|::|:..:|:....:...    |..:..|.|.::  :|...|:..|...|..:|..|.|..
Zfish    85 AAFKLLKRLRHEWVNIAKFTQQ----SLYQEFQTLLDYSLIPELEDINSAALGLIGLQEIYKLYP 145

  Fly   157 PEISHGFLNGKQYNVSLTVLDTYAMGQILFDQKNYLAAASWIYQSVVLMEAFSMAAPLEISKNE- 220
            ..|:.        ...|:..:.|.:|.:.:::..:..|..|...|:..:..||     ..:||:
Zfish   146 HNITK--------ETPLSADEAYYIGLVAYEEDKFQHAFLWFLHSLNRLTDFS-----STTKNDL 197

  Fly   221 ---------------VRMVYAETLLKLNQHADALKV-------VNIALTDNPHDIKLLLKKSEIE 263
                           |.:.:.:.||.|:...:.:||       :.:..|.||          :|.
Zfish   198 LRFLSSSAYQFGSLPVAIYFGQKLLNLDPSNEEIKVQLGLYRLIRLQRTSNP----------DIF 252

  Fly   264 TMIRTGTNNAPPVKVQATGVPTAYQIGCRGQFPPSADSK---LYCLYNR-TTSPFLILAPLKMEL 324
            | :.|.:||             :|:..|||:.......:   |.|.|:. ..:|.|:.||:|.|.
Zfish   253 T-LNTQSNN-------------SYEALCRGEVDERTSKRQRALSCRYSTGGGNPRLMYAPVKEEE 303

  Fly   325 VGLDPYMVLYHDVLSPKEIKELQGMATPGLKRATVYQASSGRNEVVKTRTSKVAWFPD-GYNPLT 388
            :..:|.::.||||:|..||:.|:.:|.|.|.|     :.:|...:...|||:..:..: |   ..
Zfish   304 LWDEPKIIRYHDVISDTEIETLKDIARPELTR-----SQTGWGVISDIRTSQSVFLEEVG---TV 360

  Fly   389 VRLNARISDMTGFNLYGSEMLQLMNYGLGGHYDQHYDFFNKTNSNMTAMSGDRIATVLFYLTDVE 453
            .|::.||:|:||.::..:|.|.:.|||:||.|..|:|..::.|        :|.||.|.|::|||
Zfish   361 ARISQRIADITGLSVESAEKLHVQNYGIGGRYTPHFDTGDEVN--------ERTATFLIYMSDVE 417

  Fly   454 QGGATVFPNIRKAVFPQRGSVVMWYNLKDNGQIDTQTLHAACPVIVGSKWVCNKWIREREQIFSR 518
            .||||||.|:..||.|::||.|.||||..||::|.:|.||.|||:||:|||.||||.|..|.|.|
Zfish   418 VGGATVFTNVGVAVKPEKGSAVFWYNLHKNGELDLKTKHAGCPVLVGNKWVANKWIHEFGQEFRR 482

  Fly   519 PC 520
            ||
Zfish   483 PC 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaPV	NP_733395.1	P4Ha_N	35..164	CDD:285528	30/130 (23%)
		TPR_11	179..250	CDD:290150	16/93 (17%)
		TPR repeat	179..213	CDD:276809	7/33 (21%)
		TPR repeat	218..248	CDD:276809	8/52 (15%)
		P4Hc	339..510	CDD:214780	72/171 (42%)
zgc:152670	NP_001070123.2	P4Ha_N	26..150	CDD:285528	30/127 (24%)
zgc:152670	NP_001070123.2	P4Hc	318..474	CDD:214780	72/171 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920