DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaPV and CG15864

DIOPT Version :9

Sequence 1:	NP_733395.1	Gene:	PH4alphaPV / 43640	FlyBaseID:	FBgn0051015	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_652183.2	Gene:	CG15864 / 50001	FlyBaseID:	FBgn0040528	Length:	490	Species:	Drosophila melanogaster

Alignment Length:	503	Identity:	185/503 - (36%)
Similarity:	268/503 - (53%)	Gaps:	60/503 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 EESHCTSVAGMVKLLDLEAQLIDNLEDYAVELEKKLQTVRRSITSLRLENDKARSSTEEYLSNPL 93
            ::|:..|...::|||::|.:|:|||:.|...|:.|...:.||:..:..||.:.:|..|.||.|||
  Fly    29 KKSYAASTMELMKLLEVEDELVDNLKGYVKTLKMKFNLMERSLIDMSRENMEMKSDYESYLGNPL 93

  Fly    94 NSFSLIRRMNRDWIIWQLYM----DDPVGISQVERIQELREHMPTHTDVEEAVTALDRIQSTYGL 154
            |||.||.|::..|..|..|.    ::.:|  .:|..:.:|:.:||.:|:::|...:..:.|.|.|
  Fly    94 NSFRLIHRLHTSWRKWYQYAIKVENNALG--HIENARLMRKMLPTSSDLQQACRGIHDLMSFYDL 156

  Fly   155 KVPEISHGFLNG-KQYNVSLTVLDTYAMGQILFDQKNYLAAASWIYQSVVLMEAFSMAAPLEISK 218
            |..|::.|.|.| .|....||..|..|:|:....::....|.:|...|::..|.       :..|
  Fly   157 KPEELAAGNLAGYSQPGTGLTAYDCLALGEFSVQKREDDLAEAWYNLSLIRFEN-------KFDK 214

  Fly   219 NEVRMVYAETLLKLNQHADALKVVNIALTDNPHDI----KLLLKKSEIETMIRTGTNNAPPVKVQ 279
            ..|...:...|.|..|..||.    ....:.|..|    :::..|.|:.|.    .|.|  |.||
  Fly   215 YRVHKAWGLLLAKNKQLTDAF----YHFENKPEGIIASNEVIHFKEELSTK----QNCA--VVVQ 269

  Fly   280 ATGVPTAYQIGCRGQFPPSADSKLYCLYNRTTSPFLILAPLKMELVGLDPYMVLYHDVLSPKEIK 344
                               ..|:|:|.||.||:||..:||||||.:|||||||::|||:...||.
  Fly   270 -------------------KPSRLHCRYNTTTTPFTRIAPLKMEELGLDPYMVVFHDVIYDTEID 315

  Fly   345 ELQGMATPGLKRATVYQASSGRNEVVKTRTSKVAWFPDGYNPLTVRLNARISDMTGFNLYGSEML 409
            .:...:..||.     ...||:...|  ||||.::..|...     ||.|::|||||::..|:..
  Fly   316 GMLNSSNFGLS-----LTDSGQKSEV--RTSKDSYIVDAKT-----LNERVTDMTGFSMEMSDPF 368

  Fly   410 QLMNYGLGGHYDQHYDFFNKTNSNMTAMSGDRIATVLFYLTDVEQGGATVFPNIRKAVFPQRGSV 474
            .|:||||||||..||||...||:. ....|||||||||||.:|:.||||:||.|...|.|::||.
  Fly   369 SLINYGLGGHYMLHYDFHEYTNTT-RPKQGDRIATVLFYLGEVDSGGATIFPMINITVTPKKGSA 432

  Fly   475 VMWYNLKDNGQIDTQTLHAACPVIVGSKWVCNKWIREREQIFSRPCLK 522
            |.||||.::|.::.::||:|||||.|||:|..|||.|..|:|..||:|
  Fly   433 VFWYNLHNSGAMNLKSLHSACPVISGSKYVLTKWINELPQMFVTPCMK 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaPV	NP_733395.1	P4Ha_N	35..164	CDD:285528	45/132 (34%)
		TPR_11	179..250	CDD:290150	13/70 (19%)
		TPR repeat	179..213	CDD:276809	6/33 (18%)
		TPR repeat	218..248	CDD:276809	7/29 (24%)
		P4Hc	339..510	CDD:214780	78/170 (46%)
CG15864	NP_652183.2	P4Ha_N	35..166	CDD:285528	45/132 (34%)
		metallo-dependent_hydrolases	<237..>306	CDD:294200	32/93 (34%)
		P4Hc	313..467	CDD:214780	77/166 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461766
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900