DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaPV and p4ha2

DIOPT Version :9

Sequence 1:	NP_733395.1	Gene:	PH4alphaPV / 43640	FlyBaseID:	FBgn0051015	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	XP_012814344.2	Gene:	p4ha2 / 493342	XenbaseID:	XB-GENE-957618	Length:	537	Species:	Xenopus tropicalis

Alignment Length:	516	Identity:	179/516 - (34%)
Similarity:	277/516 - (53%)	Gaps:	38/516 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 TSVAGMVKLLDLEAQLIDNLEDYAVELEKKLQTVRRSITSLRLENDKARSSTEEYLSNPLNSFSL 98
            ||...|..|:..|..|:.:|::|..|.|::|..::|..:.:...:.::.:..|.||.:|:|::.|
Frog    25 TSTGQMTDLIFRERDLLQSLKEYIREEEERLSKIKRWASEVDELSSRSTADPEGYLGHPVNAYKL 89

  Fly    99 IRRMNRDWIIWQ--LYMDDPVGISQVERIQELREHMPTHTDVEEAVTALDRIQSTYGLKVPEISH 161
            ::|.|.||...:  :..|...|.  :......||:.||..|...|..||.|||.||.|....|:.
Frog    90 VKRFNTDWSSLENLVLQDSAKGF--IANFTFQREYFPTEEDETGAARALMRIQDTYKLDPDVIAK 152

  Fly   162 GFLNGKQYNVSLTVLDTYAMGQILFDQKNYLAAASWIYQSVVLMEAFSMAAPLEISKNEVRMVYA 226
            |.|.|..|..||:..|::.||:|.:...:|.....|:.|::..|:....|.   ::|.:|....:
Frog   153 GKLPGTNYISSLSADDSFGMGKIAYHDGDYYHTVLWMQQALKQMDEGEDAV---VNKVDVLDYLS 214

  Fly   227 ETLLKLNQHADALKVVNIALTDNP-HD-----IKLLLK-----KSEIETMIRTGTNNAPPVKVQA 280
            .|:.:|.....||::....|..:| ||     :|...|     |:|::....|.|.:|    .:.
Frog   215 YTVFQLGDVPRALELTKRLLALDPNHDRAVNNLKYFEKMQEKQKAELKQNESTNTESA----TRQ 275

  Fly   281 TGVPT----------AYQIGCRGQ---FPPSADSKLYCLY-NRTTSPFLILAPLKMELVGLDPYM 331
            .||.:          .|:..|||:   ..|....:|:|.| |...||:|||:|:|:|.....|.:
Frog   276 PGVYSRPLDYLPERDVYEALCRGEGVKMNPRRQRRLFCRYHNGNRSPYLILSPVKVEDEWDSPRI 340

  Fly   332 VLYHDVLSPKEIKELQGMATPGLKRATVYQASSGRNEVVKTRTSKVAWFPDGYNPLTVRLNARIS 396
            |.|.:.||.:||.:::.:|.|.|.||||....:|...|...|.||.||..:..:|:..|:|.|:.
Frog   341 VRYLNALSDEEIAKIKELAKPKLARATVRDPKTGVLSVANYRVSKSAWLEENDDPVIARVNLRMQ 405

  Fly   397 DMTGFNLYGSEMLQLMNYGLGGHYDQHYDFFNKTNSNMTAM--SGDRIATVLFYLTDVEQGGATV 459
            .:||..:..:|:||:.|||:||.|:.|:||..|...::...  :|:|:||.|.|::|||.|||||
Frog   406 AITGLTVDTAELLQVANYGMGGQYEPHFDFSRKDEPDVFKRLGTGNRVATFLNYMSDVEAGGATV 470

  Fly   460 FPNIRKAVFPQRGSVVMWYNLKDNGQIDTQTLHAACPVIVGSKWVCNKWIREREQIFSRPC 520
            ||:...|::|::|:.|.||||..:|:.|.:|.||||||:||||||.|||..||.|.|.|||
Frog   471 FPDFGAAIWPKKGTAVFWYNLFRSGEGDYRTRHAACPVLVGSKWVSNKWFHERGQEFLRPC 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaPV	NP_733395.1	P4Ha_N	35..164	CDD:285528	39/130 (30%)
		TPR_11	179..250	CDD:290150	15/70 (21%)
		TPR repeat	179..213	CDD:276809	8/33 (24%)
		TPR repeat	218..248	CDD:276809	7/29 (24%)
		P4Hc	339..510	CDD:214780	78/172 (45%)
p4ha2	XP_012814344.2	P4Ha_N	27..113	CDD:400573	22/87 (25%)
		TPR repeat	166..201	CDD:276809	8/34 (24%)
		TPR repeat	206..236	CDD:276809	7/29 (24%)
		P4Hc	348..521	CDD:214780	78/172 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010