DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaPV and CG31021

DIOPT Version :9

Sequence 1:	NP_733395.1	Gene:	PH4alphaPV / 43640	FlyBaseID:	FBgn0051015	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_733392.2	Gene:	CG31021 / 43638	FlyBaseID:	FBgn0051021	Length:	453	Species:	Drosophila melanogaster

Alignment Length:	485	Identity:	137/485 - (28%)
Similarity:	232/485 - (47%)	Gaps:	44/485 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LLDLEAQLIDNLEDYAVELEKKLQTVRRSITSLRLENDKARSSTEEYLSNPLNSFSLIRRMNRDW 106
            :|:||..|:.|:.|||.:||:|:..:...:....::.:.|....|:|||||||||.|||.|::||
  Fly     1 MLNLERNLLQNMRDYAEKLEEKIDLINNYVEDYNVDIEDANEDPEKYLSNPLNSFRLIRHMHQDW 65

  Fly   107 IIWQLYMDDPVGISQVERIQELREHMPTHTDVEEAVTALDRIQSTYGLKVPEISHGFLNGKQYNV 171
            :.||:||:|.|....|::::.|...:|......:|..::..:...||.:..::.  ..:.:..::
  Fly    66 VGWQVYMEDLVAPEAVQKVESLLPQLPQKEAFRKAARSVHSLTQFYGYEPADLV--AKDERSSSL 128

  Fly   172 SLTVLDTYAMGQILFDQKNYLAAASWIY---QSVVLMEAFSMAAPLEISKNEVRMVYAETLLKLN 233
            .|:.||.|.:|..|:::::||.||.|:.   .:..|.....:..||...:.:|......||||||
  Fly   129 HLSPLDCYHLGLELYEEQDYLGAAKWLQVAAHNYTLSRHRDLFNPLGAPRWQVYRDLGRTLLKLN 193

  Fly   234 QHADALKVVNIALTDNPHDIKLLLKKSEIETMIRTGTNNAPPVKVQATGVPTAYQIGCRGQFPPS 298
            :.. |......||..|..::.|:.:..::| :........|.:.:|..  ||..:..|||:. |.
  Fly   194 RQC-AYDAYESALRLNSQNVHLMKEAGQME-LFSLRDPMEPILDLQPK--PTVLEKYCRGEV-PR 253

  Fly   299 ADSKLYCLYNRTTSPFLILAPLKMELVGLDPYMVLYHDVLSPKEIKELQGM--ATPGLKRATVYQ 361
            ...:|.|..|.....||..||:|.|.:..||:::||...:..:||:.::..  ..|...|..:..
  Fly   254 HQGRLTCELNDWVHSFLAYAPIKFEDLQQDPFIILYPGSIYEQEIRHVENAYERCPPNDRFELKL 318

  Fly   362 ASSGRNEVVKTRTSKVAWFPDGYNPLTVRLNARISDMTGF-----NLYGSEMLQLMNYGLGGHYD 421
            ..||.:            ..|||:|:..|:|.||.||.|.     ..|..|..||      ..::
  Fly   319 GISGCS------------ISDGYSPVLKRINERILDMAGVEKTWDTFYIVEYAQL------APFE 365

  Fly   422 QHYDFFNKTN-SNMTAMSGDRI-ATVLFYLTDVEQGGATVFPNIRKAVFPQRGSVVMWYNLKDNG 484
            ....|.|.|. ..:..|:.:.: |.|:.:|.||..|||...||....|.|:||:|::.:   :|.
  Fly   366 PFKLFRNSTKFPKLNLMNFEDVEAKVIIFLKDVTLGGAFTMPNGDILVQPKRGNVLITF---ENE 427

  Fly   485 QIDTQTLHAACPVIVGSKWVCNKWIREREQ 514
            :..|    ..||:|.|:..|..|:|.:.::
  Fly   428 EHST----TICPIIEGTGLVMIKFIMKTDE 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaPV	NP_733395.1	P4Ha_N	35..164	CDD:285528	40/121 (33%)
		TPR_11	179..250	CDD:290150	21/73 (29%)
		TPR repeat	179..213	CDD:276809	9/36 (25%)
		TPR repeat	218..248	CDD:276809	10/29 (34%)
		P4Hc	339..510	CDD:214780	48/179 (27%)
CG31021	NP_733392.2	P4Ha_N	1..119	CDD:285528	40/117 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452354
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391515at2759
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.990