DRSC/TRiP Functional Genomics Resources

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Protein Alignment PH4alphaPV and PH4alphaNE2

DIOPT Version :10

Sequence 1:NP_733395.1 Gene:PH4alphaPV / 43640 FlyBaseID:FBgn0051015 Length:525 Species:Drosophila melanogaster
Sequence 2:NP_733378.1 Gene:PH4alphaNE2 / 43628 FlyBaseID:FBgn0039783 Length:542 Species:Drosophila melanogaster


Alignment Length:545 Identity:183/545 - (33%)
Similarity:288/545 - (52%) Gaps:44/545 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 WLLPVRVLLTYQVLLLLLRQAKGEESHCTSVAGMVKLLDLEAQLIDNLEDYAVELEKKLQTVRRS 70
            |.|.:..:|...:....||:...::....||..|..:|:||..|:.|:|..|..|.:|.:|::..
  Fly     4 WRLVLLGMLYLSLSFGQLRENNAQQRFARSVVNMDDMLNLEDDLVSNVEKLAEALARKAKTIKWG 68

  Fly    71 ITSLRLENDKARSSTEEYLSNPLNSFSLIRRMNRDWIIWQLYMDDPVGISQVERIQELREHMPTH 135
            :..:.....:.:||.|.: :||:::|||||.|..:|::|.||::.|||..::..:......:|.:
  Fly    69 VFKMMKRRQEYKSSMEIF-ANPIDTFSLIRHMQSNWLMWLLYLETPVGQEELFFVDSRMPLLPKY 132

  Fly   136 TDVEEAVTALDRIQSTYGLKVPEISHGFLNGKQYNVSLTVLDTYAMGQILFDQKNYLAAASWIYQ 200
            .|..:|...:.::|:||.:...:|:.|.|:|.|||.||..:|..|:|..|.:...:.||..||..
  Fly   133 FDFIDAAEGIRKMQATYQMFSSDIAKGLLDGVQYNSSLKPIDCLAIGLHLMNNSRWYAAEQWISA 197

  Fly   201 SVVLMEAFSMAAPLEISKN----EVRMVYAETLLKLNQHADALKVVNIALTDNPHDIKL-----L 256
            |:...:..|....:|:.:.    ::..:..:..:|...|..||:...:||..:|||.::     :
  Fly   198 SIEAYDQKSSQTDMELLRGPKLADLCRILGQVQMKQRNHEGALQAYQVALKLSPHDPEIYEEYRI 262

  Fly   257 LKK-----SEIETMIRTGTNN-----APPVKVQATGVPTAYQIGCRG--QFPPSADSKLYCLYNR 309
            |:|     |:||.:.:...|:     .||.              |.|  |.|.:. |.|||:||.
  Fly   263 LEKRDLTLSDIEPIEQDKDNSHERLVLPPC--------------CSGRCQVPRNL-SNLYCVYNH 312

  Fly   310 TTSPFLILAPLKMELVGLDPYMVLYHDVLSPKEIKELQGMATPGL--KRATVYQASSGRNEVVKT 372
            .|||||.|||:|.|::.:||::||.||::|.||...::..:...:  ...|...||....:|...
  Fly   313 VTSPFLQLAPIKTEILSIDPFVVLLHDMISQKESTLIRTSSKEHMLPSATTDPDASDDETQVDTY 377

  Fly   373 RTSKVAWFPDGYNPLTVRLNARISDMTGFNLYGSEMLQLMNYGLGGHYDQHYDFF--NKTNSNMT 435
            ||||..|:...:|..|.::..|:.|.||.::..:|..|::||||||.::.|.|..  .|...|.|
  Fly   378 RTSKSVWYSSDFNDTTKKITERLGDATGLDMNSTEFYQVINYGLGGFFETHLDMLLSEKNRFNGT 442

  Fly   436 AMSGDRIATVLFYLTDVEQGGATVFPNIRKAVFPQRGSVVMWYNLKDNGQIDTQTLHAACPVIVG 500
            :   |||||.||||.:|.|||.|.||.:...||||.||.:.||||...|.....:||..||||||
  Fly   443 S---DRIATTLFYLNEVRQGGGTYFPRLNLTVFPQPGSALFWYNLDTKGNDHMGSLHTGCPVIVG 504

  Fly   501 SKWVCNKWIREREQIFSRPCLKKRM 525
            ||||.:|||.:..|.|:|||::..:
  Fly   505 SKWVMSKWINDMGQEFTRPCVESSL 529

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PH4alphaPVNP_733395.1 P4Ha_N 35..166 CDD:462433 40/130 (31%)
NrfG 179..>256 CDD:443378 19/85 (22%)
TPR repeat 179..213 CDD:276809 9/33 (27%)
TPR repeat 218..248 CDD:276809 6/33 (18%)
P4Hc 339..510 CDD:214780 72/174 (41%)
PH4alphaNE2NP_733378.1 P4Ha_N 33..163 CDD:462433 40/130 (31%)
TPR repeat 175..200 CDD:276809 8/24 (33%)
TPR_16 176..254 CDD:433202 18/77 (23%)
NrfG 217..>260 CDD:443378 9/42 (21%)
TPR repeat 219..249 CDD:276809 6/29 (21%)
P4Hc 342..513 CDD:214780 71/173 (41%)

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