DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaPV and CG18231

DIOPT Version :9

Sequence 1:	NP_733395.1	Gene:	PH4alphaPV / 43640	FlyBaseID:	FBgn0051015	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_649045.2	Gene:	CG18231 / 40026	FlyBaseID:	FBgn0036796	Length:	470	Species:	Drosophila melanogaster

Alignment Length:	504	Identity:	149/504 - (29%)
Similarity:	254/504 - (50%)	Gaps:	71/504 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 TSVAGMVKLLDLEAQLIDNLEDYAVELEKKLQTVRRSITSLRLENDKARSSTEEYLSNPLNSFSL 98
            :|:..::|||::|...|.|::.|..:|.:|::.::..|.|:..|..::....|:|:.||:|:|||
  Fly    18 SSITRLLKLLEMEEIFITNIKAYTNKLAEKVKNLQAYIDSVDYEFQQSFEDREKYVGNPINAFSL 82

  Fly    99 IRRMNRDWIIWQLYMDDPVGISQVERIQELREHMPTHTDVEEAVTALDRIQSTYGLKVPEISHGF 163
            :||.::|...|..|....||:.::..::|:...:|...|:..::..:.||:..|.|:..|::.|.
  Fly    83 VRRTHQDLPKWHNYSQQIVGMEELFALEEIIAKVPDKKDMAYSLGEMHRIEQIYDLEAIELARGR 147

  Fly   164 LNGKQYNVSLTVLDTYAMGQILFDQKNYLAAASWIYQSVVLME----AFSMAAPLEISKNEVRMV 224
            :.||||:...::.|..|:|:..|.:::|..|:.| ::..:..|    |..:.:.|...|..:..:
  Fly   148 IQGKQYDFRPSIRDCVALGEHKFKREDYQRASMW-FRVAIKHEPEGNAEIINSILGDPKVNLYTL 211

  Fly   225 YAETLL-----KLNQH---ADALKVVNIALTD-NPHDIKLLLKKSEIETMIRTGTNNAPPVKVQA 280
            ||:::|     |.|..   |:|.|:...||.. :..|||.||.    |.:.:|.......:.|..
  Fly   212 YAKSMLIFGMIKSNPSMTIAEAKKISYEALNKASLADIKSLLN----ELLSQTDDEIVYEMNVNK 272

  Fly   281 TGVPTAYQIGCRGQFPPSADSKLYCLYNRTTSPFLILAPLKMELVGLDPYMVLYHDVLSPKEIKE 345
            | .|:.|:|||||||....:.  .|.||.|.:.||.|||||.|::..|||:|:|||||:..||.:
  Fly   273 T-KPSDYEIGCRGQFLRRRNH--VCTYNFTITEFLKLAPLKQEVLNWDPYIVIYHDVLNDDEIDK 334

  Fly   346 LQGMATPGLKRATVYQASSGRNEVVKTRTSKVAWFPDGYNPLTVRLNARISDMTGFNLYGSEMLQ 410
            |                   :|.:..|...:|       ||:..|:..||:::|..:...|:...
  Fly   335 L-------------------KNHLNDTDAVEV-------NPIEKRIFQRINELTRLSFEHSDQQI 373

  Fly   411 LMNYGLGGHYDQHYDFFNKTNSNMTAMSGDRIATVLFYLTDVEQGGATVFPNIRKAVFPQRGSVV 475
            :...|...|  :|...:.|             .|:||:|.:||.|||.|||.::.:||||:||.:
  Fly   374 VSKNGPRTH--KHKKEYLK-------------GTLLFFLNNVELGGAMVFPKLKISVFPQKGSCL 423

  Fly   476 MWYNLKDNGQIDTQTLHAACPVIVGSKWVCNKWIREREQIFSRPCLKKR 524
            .|:|     .:|.::....|||:.|:|.|    |.::.....||...|:
  Fly   424 FWHN-----TLDPRSEPLECPVLQGNKRV----ITQKGAYNGRPMQYKK 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaPV	NP_733395.1	P4Ha_N	35..164	CDD:285528	37/128 (29%)
		TPR_11	179..250	CDD:290150	20/83 (24%)
		TPR repeat	179..213	CDD:276809	8/37 (22%)
		TPR repeat	218..248	CDD:276809	11/37 (30%)
		P4Hc	339..510	CDD:214780	44/170 (26%)
CG18231	NP_649045.2	P4Ha_N	19..148	CDD:285528	37/128 (29%)
CG18231	NP_649045.2	2OG-FeII_Oxy	322..449	CDD:304390	49/176 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461887
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900